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ProteomicsIntegrated top-down and bottom-up mass spectrometry enables precise characterization of proteoforms and their post-translational modifications within the protein corona
Precise characterization of proteins and proteoforms within the protein corona is essential for developing safer and more effective nanomedicines for diagnostic and therapeutic applications. Although the protein corona phenomenon has been recognized in nanomedicine for nearly two decades, the applic...
ORGANISM(S): Homo sapiens (Human) 
2026-05-14 | PXD077545 | Pride
Bup Peptide Ptm Proteoform Protein corona Tdp 
ProteomicsThromboxane-A Synthase 1 as a Potential Dual Biomarker for Metastatic Prostate Cancer and Atherosclerosis: Insights from a Nanomedicine Protein Corona, Machine Learning, and Actual Causality Approaches
Prostate cancer (PC) is the most common cancer among men in the United States, while atherosclerosis (ASCVD) is the most prevalent cardiovascular disease (CVD) associated with it. CVD, particularly ASCVD, has been shown to contribute to metastatic prostate cancer (mPC) progression. Identifying blood...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD057863 | Pride
Protein corona Bottom up proteomics Machin learning Human plasma 
ProteomicsMass spectrometry-based top-down proteomics in nanomedicine: proteoform-specific measurement of protein corona
Conventional mass spectrometry (MS)-based bottom-up proteomics (BUP) analysis of protein corona [i.e., an evolving layer of biomolecules, mostly proteins, formed on the surface of nanoparticles (NPs) during their interactions with biomolecular fluids] enabled nanomedicine community to partly identif...
ORGANISM(S): Homo sapiens (Human) 
2024-10-15 | PXD050779 | Pride
Protein corona Top-down proteomics Nanomedicine Plasma Proteoform 
ProteomicsMass Spectrometry-Based Top-Down Proteomics for Proteoform Profiling of Protein Corona
The protein corona, a layer of biomolecules—primarily proteins—that adsorb to nanoparticle (NP) surfaces in biological fluids, critically affects NP safety and their therapeutic and diagnostic functions. Additionally, the protein corona effectively reduces proteome complexity and the dynamic range o...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD060784 | Pride
Top-down proteomics Mass spectrometry Nanomedicine Protein corona 
ProteomicsOptimized MeOH/MTBE-based Protein Precipitation and Lipid Removal Enables High Enrichment of Low Molecular Weight Peptides and Proteins from Human Plasma
Low molecular weight (LMW) peptides and proteins (LMWPs, < 30 kDa) in human plasma, serving as potential biomarkers or drug targets, are endowed with a wealth of biological and clinical research values. However, the extraction of LMW species is retarded by high-abundance proteins (HAPs) and therein ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD016957 | Pride
Human Plasma Lc-ms/ms 
TranscriptomicsChronic exposure to butyl-paraben causes photosensitivity disruption and memory impairment in adult zebrafish
Limited studies on neurotoxicity following chronic exposure to butyl-paraben (BuP) have been conducted. In this study, neurobehavior in zebrafish adults was assessed using a novel tank test, photomotor response tests, and T-maze tests after exposure to BuP for 28 days at the concentrations of 0, 0.0...
ORGANISM(S): Danio rerio 
2022-08-21 | GSE211530 | GEO
TranscriptomicsTargeting of Tripartite Neuron-Cancer-Immune Cell Crosstalk Augments Response to Chemotherapy and Immunotherapy
Neurotransmitter-mediated crosstalk between nerve fibers, cancer cells, and immune cells in the tumor microenvironment (TME) have been shown to promote cancer progression and immunosuppression. While there are extensive reports on sympathetic nerve fibers, effect of parasympathetic neurons on cancer...
ORGANISM(S): Mus musculus 
2026-07-21 | GSE303917 | GEO
ProteomicsTop-Down and Bottom-Up Proteomics Strategies for Characterization of Brazilian Pampa Snake, Bothrops pubescens, venom.
The genus Bothrops is responsible for most part of envenomation accidents in Brazil. Bothrops pubescens is an endemic and neglected species in the Brazilian Pampa Biome. The characterization of its venom is essential since there is no data about it and can be helpful in the discovery of active biomo...
ORGANISM(S): Bothrops pubescens 
2024-01-26 | PXD027650 | Pride
Bothrops Snake Proteome 
ProteomicsHigh-throughput plasma/serum proteomics by coupling nanoparticle protein corona-based sample preparation and capillary zone electrophoresis-tandem mass spectrometry
A high-throughput workflow for bottom-up proteomics (BUP) of human plasma using capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) and nanoparticle protein corona-assisted sample preparation is presented. The streamlined approach enabled the identification and quantification of hun...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-08-04 | PXD063043 | Pride
Nanoparticle protein corona Bottom-up proteomics High-throughput Cze-ms/ms Biomarker 
UnknownDeuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats.
Not available
S-EPMC10204800 | biostudies-literature
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