Sort   by:  
 Page size 
ProteomicsSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
Aberrant expression of the embryonal transcription factor TBXT (also known as brachyury) drives chordoma, a rare spinal neoplasm with no effective drug therapies. The gene network regulated by TBXT is poorly understood, and strategies to disrupt its abnormal activity for therapeutic purposes are lac...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD055982 | Pride
Tbxt Chordoma Darpin Brachyury 
ProteomicsA translational protocol for the analysis of plasma-derived extracellular vesicle proteomics
We establish here an EV purification and proteomic analysis workflow in a real world clinical setting in which we evaluate different variables, from blood collection through protein preparation for mass spectrometry (MS). We compare blood collection tubes, sample transportation and storage condition...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD058373 | Pride
Protocol Proteomics Preanalytics Liquid biopsy Plasma Extracellular vesicles Translation 
Sort   by:  
 Page size