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ProteomicsDeuterium oxide labeling methods for bulk and single muscle protein synthesis measures, and measures of integrated muscle protein synthesis and breakdown rates
This methodological pilot study explored the feasibility of an integrated tracer approach for simultaneous measurement of human skeletal muscle protein synthesis and breakdown during prolonged deuterium oxide (²H₂O) labelling. Four healthy men completed a five week protocol combining daily oral ²H₂O...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD078552 | Pride
Human Skeletal muscle Protein trunover 
ProteomicsMOE silencing of DUX4 in FSHD and UASB myoblasts
Proteomic studies in facioscapulohumeral muscular dystrophy (FSHD) could offer new insight to disease mechanisms underpinned by post-transcriptional processes. We used stable isotope (deuterium oxide; D2O) labelling and peptide mass spectrometry to investigate the abundance and turnover rates of pro...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD042374 | Pride
Human Q-exactive 
ProteomicsD2O proteome dynamics in FSHD vs UASb myoblasts
Proteomic studies in facioscapulohumeral muscular dystrophy (FSHD) could offer new insight to disease mechanisms underpinned by post-transcriptional processes. We used stable isotope (deuterium oxide; D2O) labelling and peptide mass spectrometry to investigate the abundance and turnover rates of pro...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD038818 | Pride
Human Fusion 
ProteomicsProtein synthesis during myoblast differentiation
Mole (MSR) and fractional (FSR) synthesis rates of proteins during C2C12 myoblast differentiation were investigated. Myoblast cultures supplemented with D2O during 0-24 h or 72-96 h of differentiation were analysed by LC-MS/MS to calculate protein FSR and MSR after samples were spiked with yeast alc...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021125 | Pride
C2c12  muscle  fractional synthesis rate 
ProteomicsHuman Muscle protein responses to exercise during low carbohydrate availablility
Background. Training with low carbohydrate availability (LCA) has been proposed as an independent determinant of physiological perturbations commonly attributed to low energy availability (LEA) and to increase skeletal muscle oxidative machinery, yet the effects of LCA in isolation from LEA remain u...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077494 | Pride
Human Myofibrillar Muscle Lc-ms/ms 
ProteomicsPlasma EV proteome in Rugby players
Rugby players may repeatedly incur high-impact collisions that could predispose them to neurodegenerative conditions but the processes underlying the heightened risk are currently unclear. This project investigates whether the proteome of plasma extracellular vesicles (EV) could carry putative diagn...
ORGANISM(S): Homo sapiens (Human) 
2025-11-30 | PXD061593 | Pride
Plasma Extracellular vesicles Human Lc-ms/ms 
ProteomicsExercise-responsive phosphoproteins in the heart
Endurance exercise improves cardiac performance and affords protection against cardiovascular diseases but the signalling events that mediate these benefits are largely unexplored. Phosphorylation is an widely studied post-translational modification involved in intracellular signalling, and to disco...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-08-24 | PXD006646 | Pride
Phosphoproteomics Exercise-response 
ProteomicsD2O proteome dynamics in response to energy deficit
Energy deficit has shaped human evolution, and represents a potent physiological stressor associated with improvements in lifespan and healthspan in several species. Preserving locomotive capacity has likely been essential for food procurement and survival from starvation during the hunter-gatherer ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-04 | PXD061267 | Pride
Human Deuterium oxide labelling Skeletal muscle Lc-ms/ms 
ProteomicsQuantitative verification of PLIN2 and PLIN5 peptides in human skeletal muscle via parallel reaction monitoring
Energy deficit has shaped human evolution and represents a potent physiological stressor associated with improvements in lifespan and health span in several species. Preserving locomotive capacity has likely been essential for food procurement and survival from starvation during the hunter-gatherer ...
ORGANISM(S): Homo Sapiens 
2025-11-10 | PXD061311 | panorama
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