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Renal oncocytomas are rare benign tumors of the kidney and are characterized by a deficient complex I (CI) enzyme activity of the oxidative phosphorylation (OXPHOS) system caused by mitochondrial DNA (mtDNA) mutations. Yet, little is known about the underlying molecular mechanisms and alterations of...
ORGANISM(S): Homo sapiens (Human) 
2017-11-21 | PXD007633 | Pride
Oxidative stress (OS) results from genetic defects or stressful environmental challenges that cause unchecked production of reactive oxygen species (ROS). OS has been implicated in many diseases due to its wide ranging damage to nucleic acids, proteins and lipids. Using Halobacterium salinarum NRC...
ORGANISM(S): Halobacterium salinarum 
Zoonotic pathogens that can be transmitted via food to humans have a high potential for large-scale emergencies, comprising severe effects on public health, critical infrastructures, and the economy. In this context, the development of laboratory methods to rapidly detect zoonotic bacteria in the fo...
ORGANISM(S): Francisella tularensis subsp. holarctica Francisella hispaniensis Francisella tularensis subsp. mediasiatica Lepus europaeus Francisella tularensis subsp. tularensis Francisella tularensis subsp. novicida Francisella philomiragia 
2020-06-30 | PXD013979 | Pride
LC-MS/MS based proteomics study of chromophobe renal cell carcinomas versus the adjacent healthy kidney tissues, nine patients included. The chromophobe renal cell carcinoma cells (UOK276) under different conditions were also analyzed.
ORGANISM(S): Homo sapiens (Human) 
2020-07-23 | PXD019123 | Pride
Papillary renal cell carcinoma (pRCC) is a malignant kidney cancer with a prevalence of 7-20% of all renal cell tumors. Proteome and metabolome profiles of 19 pRCC and patient-matched healthy kidney controls and transcriptome data derived from TCGA were used to elucidate the regulation of metabolic ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-06 | PXD013523 | Pride
: Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells1. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for controlling cellular behavior, but to date no su...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD027295 | Pride
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