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ProteomicsClpXP, ClpCP and ClpEP proteases effects on the Streptococcus pneumoniae proteome
In the important human pathogen, Streptococcus pneumoniae, the ClpP protease is essential for modulating virulence and the cellular stress response. Here, the Clp ATPase chaperones associate with the ClpP protease to mediate general and targeted proteolysis. To identify the ClpP-dependent function o...
ORGANISM(S): Staphylococcus aureus 
2025-05-01 | PXD061622 | Pride
Clpx Protein homeostasis Pneumococcus Clpp Streptococcus pneumoniae Clpe Clpc 
ProteomicsThe iron-regulated sRNA IsrR is involved in the display of full Staphylococcus aureus virulence in part via SaeRS activation
The Gram-positive pathogenic bacterium Staphylococcus aureus permanently colonizes the nasal mucosa in about 30% of the healthy population. However, as an opportunistic pathogen, S. aureus can also cause a variety of diseases, the treatment of which is becoming increasingly difficult due to antibiot...
ORGANISM(S): Staphylococcus aureus 
2025-04-11 | PXD055092 | Pride
Saers Virulence Staphylococcus aureus Secretome Isrr 
ProteomicsDifferential contributions of CodY, SigB and the hibernation promoting factor HPF to interactions of Staphylococcus aureus USA300 with human lung epithelial cells explained by proteome analysis
The Gram-positive bacterium Staphylococcus aureus is a leading cause of severe pneumonia. Therefore, we recently investigated the fate of S. aureus upon internalization by human lung epithelial cells. This uncovered three major adaptive responses of the bacteria, involving the SigB and CodY regulons...
ORGANISM(S): Staphylococcus aureus 
2024-09-11 | PXD044962 | Pride
Epithel cells Usa300 Hibernation promoting factor Staphylococcus aureus 
UnknownThe global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12687902 | biostudies-literature
UnknownGlobal age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535839 | biostudies-literature
UnknownGlobal burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535838 | biostudies-literature
UnknownBurden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535840 | biostudies-literature
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