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ProteomicsGel LC-MS/MS analyses of MMP cleavage of tryptophanyl-tRNA synthetase
Tryptophanyl-tRNA synthetase was incubated by MMPs, cleavage products were resolved on SDS-PAGE. Cleavage products were trypsin digested and analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-05-29 | PXD013217 | Pride
Mmp Protease Lc-ms/ms 
ProteomicsLC-MS/MS analyses of MMP cleavage fragments of tyrosyl-tRNA synthetase
Tyrosyl-tRNA synthetase was digested with MMPs after which cleavage fragments were resolved using SDS-PAGE. Major bands were digested with trypsin and analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD013197 | Pride
Mmp Protease Lc-ms/ms 
UnknownDevelopments in Glycopeptide Antibiotics.
Not available
S-EPMC5952257 | biostudies-literature
ProteomicsATOMS determination of MMP cleavage site locations in YRS
Recombinant human tyrosyl-tRNA synthetase (YRS) was cleaved using recombinant MMPs. Terminal amine oriented mass spectrometry of substrates (ATOMS) was used to identify MMP generated cleavage sites from these mixtures with LC-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2019-05-29 | PXD013366 | Pride
Mmp Protease Lc-ms/ms 
ProteomicsHDAC6 inhibition alleviates mitochondrial trafficking in novel models of Charcot-Marie-Tooth Disease Type 2A
Charcot-Marie-Tooth Disease (CMT) is a group of inherited progressive conditions affecting distal motor and sensory neurons, leading to muscle weakness, pain and loss of sensation in limbs. CMT type 2A (CMT2A) is the most common form of axonal CMT and is associated with a more severe clinical manife...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD077751 | Pride
Mitochondria Mitofusin-2 Charcot-marie-tooth disease type 2a 
ProteomicsTAILS proteomics of murine pancreatic tumors
Aberrant proteolysis by cysteine cathepsins is implicated in carcinogenesis, but knowledge of cathepsin substrates mediating tumor-promoting or suppressing effects is limited. Here we characterize tumor proteome and in vivo cathepsin substrates using cathepsin knockout mice and the RIP1-Tag2 model o...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-08 | PXD003637 | Pride
Pancreatic neuroendocrine cancer Ecm Proteomics Substrate discovery Proteolytic processing Degradation Proteases Tails n-terminomics Cysteine cathepsins 
UnknownDistinct maternal DNA methylation associations with gestational age at early and late-mid term pregnancy in a low- and middle-income country: evaluation of biological, genetic, and psychosocial contributors.
Not available
S-EPMC12512460 | biostudies-literature
ProteomicsActive Site Specificity Profiling of the Matrix Metalloproteinase Family: Proteomic Identification of 4,300 Cleavage Sites by MMPs 1, 2, 3, 7, 8, 9, 12, 13, and 14.
Background: The active site of matrix metalloproteinases (MMPs) is highly conserved, complicating the rational design of specific substrates and inhibitors for individual family members. Results: Active site specificity profiles of 9 MMPs were determined using high throughput Proteomic Identificatio...
ORGANISM(S): Homo sapiens (Human) 
2015-09-29 | PXD002265 | Pride
Ecm Pics Mmps Mass spectrometry Specificity profiling Webpics 
Transcriptomics21 Breast Cancer Genome Affymetrix SNP6 Array Data
Cancer evolves dynamically, as clonal expansions supersede or overlap one another, driven by shifting selective pressures, mutational processes and disrupted cancer genes. These processes mark the genome, such that a cancerÕs life history is encrypted in the timing, ploidy, clonality and patterns of...
ORGANISM(S): Homo sapiens 
2012-06-16 | E-MTAB-1087 | biostudies-arrayexpress
UnknownThe value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.
Not available
S-EPMC6350634 | biostudies-literature
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