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ProteomicsIn-depth quantitative proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, we identified a total of 5497 proteins in whole ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006558 | Pride
Dimethylation labeled quantification Quantitative analysis Bv2 activation 
ProteomicsTargeted proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, using label-free PRM approach which is allowing ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006556 | Pride
Targeted protoemics Quantitative analysis Label-free prm Bv2 activation 
TranscriptomicsReal-time quantitative PCR analysis of BV2 murine microglia cell line
Murine BV2 microglia cells were transfected either with siRNA negative control or siRNA against caspase-3 for 48h. Later on some the of the BV2 transfected cells were co-cultured with C6 glioma cells during 6h. We used the SA Biosciences Mouse Wound Healing PCR Array (PAMM-121Z) to quantitate gen...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-84772 | biostudies-arrayexpress
GenomicsMutant Huntingtin promotes neuronal death through cell autonomous microglial activation via myeloid lineage- determining factors
Huntington's Disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N-terminus of the huntingtin (Htt) protein. Reactive microglia and elevated cytokine levels are observed in the brains of HD patients, but the extent to which neuroinflammation results f...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54443 | biostudies-arrayexpress
TranscriptomicsTranscription profiles of BV2 microglial cell lines- unstimulated or stimulated with LPS or transfected with constitutively active Stat1 and Stat3.
Transcription profiles of BV2 microglial cell lines: unstimulated, stimulated with LPS or transfected with constitutively active Stat1 and Stat3.
ORGANISM(S): Mus musculus 
2014-06-19 | E-MEXP-3659 | biostudies-arrayexpress
TranscriptomicsEffect of small molecules on activated BV2 microglia cell line
We have developed an assay to test the neuroprotective properties of compounds using stem cellM-bM-^@M-^Sderived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated BV2 cells was tested. The...
ORGANISM(S): Mus musculus 
2012-11-03 | E-GEOD-37612 | biostudies-arrayexpress
ProteomicsProteomic study of baicalein effects on LPS-primed BV2 microglia
To comprehensively study the intracellular signaling changes and explore the underlying mechanisms of baicalein-mediated microglial responses, we employed systemic proteomic approach, using target-free SWATH mass spectra (SWATH-MS), focusing on intracellular proteins. BV2 cells were treated with LPS...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-14 | PXD030447 | Pride
Baicalein Microglia 
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_IL102, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM11210041929 | GPMDB
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_LPS_1, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320019104 | GPMDB
UnknownA three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia.
Not available
S-EPMC4128540 | biostudies-literature
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