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UnknownPI3Kα-specific inhibitor BYL-719 synergizes with cisplatin in vitro in PIK3CA-mutated ovarian cancer cells.
Not available
S-EPMC11842864 | biostudies-literature
UnknownProlonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function.
Not available
S-EPMC7569204 | biostudies-literature
UnknownCryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation.
Not available
S-EPMC8609346 | biostudies-literature
UnknownActivating PIK3CA mutation promotes adipogenesis of adipose-derived stem cells in macrodactyly via up-regulation of E2F1.
Not available
S-EPMC7393369 | biostudies-literature
TranscriptomicsRNA sequence for macrodactyly ADSCs
Macrodactyly is a congenital malformation characterized by enlargement of bone and soft tissues in limbs, typically with excessive accumulation of adipose tissues. Although gain-of-function mutation of PIK3CA has been identified in macrodactyly, the mechanism of PIK3CA mutation in adipose accumulati...
ORGANISM(S): Homo sapiens 
2020-06-05 | GSE151840 | GEO
GenomicsRNA sequence for macrodactyly ADSCs
RNA sequence for macrodactyly ADSCs
PRJNA637388 | ENA
UnknownActivating PIK3CA mutations in adipose-derived stem cells drive mutant-like phenotypes of wild-type cells in macrodactyly.
Not available
S-EPMC12217521 | biostudies-literature
UnknownInhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer.
Not available
S-EPMC6679163 | biostudies-literature
UnknownCryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.
Not available
S-EPMC9674216 | biostudies-literature
ProteomicsTMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing
The development of the TMTpro-16plex series expanded the breadth of commercial isobaric tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described 16plex reagents, the proline-based TMTpro molecule can accommodate two additional combinations of heavy carbon and nitrogen iso...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD024275 | Pride
Real-time search Eclipse Byl-719 Pten Kin-193 18plex Tmtpro Mcf10a 
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