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TranscriptomicsRadiation-induced bystander effects and gene expression in cells deficient for RAD9
Background: The radiation bystander response is an important component of the overall response of cells to radiation and critical to understanding health risks of radiation exposure to humans. The mechanism of radiation response includes inter-cellular signaling and intra-cellular communication by w...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-55869 | biostudies-arrayexpress
TranscriptomicsNormal human fibroblast cell line bystander effects by Carbon ion irradiation
We have recently investigated the response of irradiated and bystander fibroblasts to heavy ions in confluent cultures exposed randomly to broadbeam and selectively to precision microbeam that target a predefined fraction of cells with counted number of particle(s), respectively, and found the diffe...
ORGANISM(S): Homo sapiens 
2008-09-02 | E-GEOD-8993 | biostudies-arrayexpress
TranscriptomicsIMR90 4hr bystander experiment 0.5Gy alpha particle strip dish format
Radiation affects tissue and cellular integrity at the level of DNA, protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and tissue and radiation induced bystander effects are significant to exposed individuals in accidental or ...
ORGANISM(S): Homo sapiens 
2008-12-28 | E-GEOD-12435 | biostudies-arrayexpress
TranscriptomicsIMR90 bystander experiment 0.5 Gy alpha particle
The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. It raises concerns for the interpretation of risks from exposure to low doses of ionizing radiation. Sparse data exists about the bystander signaling mechanisms...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-18760 | biostudies-arrayexpress
TranscriptomicsIMR90 radiation bystander time-course experiment 0.5Gy alpha particle
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the contribution of genome level changes in neighboring bystander cells to tissue and organ stress after irradiation. The timing of these ...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-21059 | biostudies-arrayexpress
ProteomicsProteomic analysis of bystander effects induced by irradiated chondrosarcoma cells
To understand the cellular response of bystander cells, we performed a 2D gel-based proteomic study of the chondrocyte receiving the conditioned medium of low dose irradiated chondrosarcoma cells. The proteomic analysis of the bystander chondrocytes highlighted 20 proteins spots that were significan...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD025187 | Pride
Proteomic analysis Chondrosarcoma Bystander signalling Secretome 
UnknownDNA damage in human skin and the capacities of natural compounds to modulate the bystander signalling.
Not available
S-EPMC6936251 | biostudies-literature
UnknownEvidence for bystander signalling between human trophoblast cells and human embryonic stem cells.
Not available
S-EPMC4501009 | biostudies-literature
TranscriptomicsBystander response to low dose (0.5 Gy) of alpha-particles in a human 3-dimensional skin model at 4h post-irradiation
Ionizing radiation (IR) not only affects cells that are directly irradiated but also their non-irradiated neighbors, which show responses known as bystander effects. While bystander and direct responses have several common end points including apoptosis and micronucleation, chromatin remodeling and ...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-23804 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to TGFβ1 and conditioned media in mammary epithelial cells
To investigate TGFβ1 (a key member of the TGFβ superfamily) signaling in non-cancerous and cancerous cells derived from breast epithelium and what further response it might generate, we treated the cells with TGFβ1 or with conditioned media. We selected MCF10A non-tumorigenic breast epithelial cells...
ORGANISM(S): Homo sapiens 
2024-12-01 | E-MTAB-13865 | biostudies-arrayexpress
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