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MetabolomicsC2C12 cell line knock out SCD1 or SCD2

Lipidomic profiling was performed to compare control, SCD1-knockout, and SCD2-knockout C2C12 cells under standard culture conditions. Cell pellets were collected from routinely cultured cells, rapidly frozen, and stored at −80°C prior to lipid extraction and LC–MS/MS analysis. The study aimed to ...

2026-06-23 | MTBLS14693 | MetaboLights
MetabolomicsLipidomic profiling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation with oleic acid supplementation
This study investigated the lipidomic remodeling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation. Scd1 or Scd2 knockout cells and corresponding control cells were induced to undergo brown adipocyte-like differentiation for 96 h. To evaluate whether exogenous monounsat...
2026-06-23 | MTBLS14692 | MetaboLights
MetabolomicsResveratrol metabolism in HepG2 (human hepatocytes), HaCaT (human keratinocytes), and C2C12 (mouse myoblasts)
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
MTBLS127 | MetaboLights
MetabolomicsSingle cell lipidome analysis of phosphatidylcholines and spingomyelins from HepG2 and C2C12 cells
Not available
ORGANISM(S): Homo sapiens 
ST002366 | MetabolomicsWorkbench
TranscriptomicsmiR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.
We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics result...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-63454 | biostudies-arrayexpress
TranscriptomicsGenes modulated by rhBMP2 and rhBMP7 during osteoblastic differentiation of C2C12 cells
This study analyses the gene expression profile of pre-osteoblastic C2C12 mice cells during osteodifferentiation in control and induced by rhBMP2 and rhBMP7 using DNA microarrays. Genes which were already known to be activated by BMP2, to be also activated by rhBMP7, indicating that BMP7 induces the...
ORGANISM(S): Mus musculus 
2011-11-17 | E-GEOD-23783 | biostudies-arrayexpress
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
TranscriptomicsTEAD4 occupied genes in differentiated C2C12 myoblasts
The TEAD (1-4) transcription factors comprise the conserved TEA/ATTS DNA binding domain recognising the MCAT element in the promoters of muscle-specific genes. Despite extensive genetic analysis, the function of TEAD factors in muscle differentiation has proved elusive due to redundancy amongst the ...
ORGANISM(S): Mus musculus 
2011-08-21 | E-GEOD-29208 | biostudies-arrayexpress
TranscriptomicsThe transcriptomic signature of myostatin inhibitory influence on the differentiation of mouse C2C12 myoblasts
GDF8 (myostatin) is a unique cytokine strongly affecting the skeletal muscle phenotype in human and animals. The aim of the present study was to elucidate the molecular mechanism of myostatin influence on the differentiation of mouse C2C12 myoblasts, using the global-transcriptome analysis with the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-59674 | biostudies-arrayexpress
ProteomicsLabel-free quantification of proteomic changes during C2C12 myoblast differentiation
Global proteome comparison between five cell populations isolated during a 4-day differentiation process in C2C12 myoblasts. A total of 5 replicates were in-column digested and data was collected in data independent acquisition mode on a Lumos Tribrid instrument for label free-quantification of prot...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-05-01 | MSV000094656 | MassIVE
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