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GenomicsAn ER-anchored peptide C4orf3/ALN controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue
An ER-anchored peptide C4orf3/ALN controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue
PRJNA1118717 | ENA
TranscriptomicsAn ER-anchored peptide C4orf3/ALN controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue
Adipose tissue thermogenesis contributes to energy balance via mitochondrial uncoupling protein 1 (UCP1) and UCP1-independent pathways. Among UCP1-independent thermogenic mechanisms, one involves Ca2+ cycling via SERCA2b in subcutaneous adipose tissues; however, the molecular underpinnings of this p...
ORGANISM(S): Mus musculus 
2025-03-28 | GSE268770 | GEO
ProteomicsNew molecular insights into atrial fibrillation due to obscurin Ig58/59 deletion
Obscurins are giant, modular, cytoskeletal proteins that regulate striated muscle structure and function. Immunoglobulin domains 58/59 (Ig58/59) of obscurin interact with diverse proteins including titin variants and phospholamban. Mutations within Ig58/59 that alter these binding interactions have ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-11 | PXD028904 | Pride
Arrhythmia Z-disk Ca2+ cycling Obscurin Atrial fibrillation 
UnknownLoss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling.
Not available
S-EPMC9074988 | biostudies-literature
UnknownA Spatiotemporal Ventricular Myocyte Model Incorporating Mitochondrial Calcium Cycling.
Not available
S-EPMC6990377 | biostudies-literature
UnknownCa2+ alternans in a cardiac myocyte model that uses moment equations to represent heterogeneous junctional SR Ca2+.
Not available
S-EPMC2905118 | biostudies-literature
UnknownReceptor occupancy regulates Ca2+ entry and intracellular Ca2+ redistribution in activated human platelets.
Not available
S-EPMC1137430 | biostudies-literature
UnknownNovel Analysis Software for Detecting and Classifying Ca2+ Transient Abnormalities in Stem Cell-Derived Cardiomyocytes.
Not available
S-EPMC4550257 | biostudies-literature
UnknownInhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes.
Not available
S-EPMC3983106 | biostudies-literature
TranscriptomicsTransgenic mice carrying the human PLN gene
These mice have been genetically modified so that the mouse PLN gene has been replace with the human PLN gene. Phopspholamban (PLN), the reversible inhibitor of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a), is a key regulator of myocyte Ca2+-cycling with a significant role in heart failure....
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-20172 | biostudies-arrayexpress
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