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ProteomicsDynamic protein interactions of the Polycomb Repressive Complex 2
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene repression. Although three subunits, EZH1/2, SUZ12 and EED, fo...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD004462 | Pride
Protein interactions Polycomb reprssor complex 2 
ProteomicsDynamic protein interactions of the Polycomb Repressive Complex 2
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene repression. Although three subunits, EZH1/2, SUZ12 and EED, fo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080739 | MassIVE
ProteomicsInvestigating the effect of molecular crowding agents on protein stability in a bacterial proteome
Molecular crowding refers to the restriction of space available for molecular mobility in solution due to the presence of other macromolecules. Crowding can influence biological phenomena such as protein stability and folding, diffusion, enzyme kinetics, molecular interactions, and phase separation....
ORGANISM(S): Bacteria Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 
2026-02-23 | PXD067043 | Pride
Thermal proteomics  cupriavidus necator  macromolecular crowding 
ProteomicsThermal Proteome Analysis of nutrient stress in Cupriavidus necator expression dataset
The facultative chemolithoautotroph Cupriavidus necator is capable of heterotrophic growth on diverse carbon sources or of autotrophic growth using CO2 fixation with H2 as an energy source. Under stress conditions, it is capable of producing biodegradable polyesters (polyhydroxyalkanoates, PHAs) as ...
ORGANISM(S): Bacteria Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 
2025-11-10 | PXD062592 | Pride
Expression proteomics Thermal proteomics 
ProteomicsIPs of SETD1A COMPASS-HUMAN LC-MSMS
Mapping physical interactions of SETD1A COMPOASS in HEK293T cells using endogenous immunoprecipitation followed by label-free quantitative proteomics. We found a novel protein interacts with SETD1A, which is RAD18 (DNA damage repair protein).
ORGANISM(S): Homo sapiens (Human) 
2019-06-13 | PXD012549 | Pride
Lc-msms Human Setd1a compass 
TranscriptomicsPolycomb-like 2 associates with PRC2 and is required for mouse embryonic stem cell
Polycomb group (PcG) proteins are highly conserved epigenetic transcriptional repressors important for the control of numerous developmental gene expression programs and have recently been implicated in the modulation of embryonic stem cell (ESC) identity. We identified the PcG protein PCL2 (polycom...
ORGANISM(S): Mus musculus 
2010-02-22 | E-GEOD-16364 | biostudies-arrayexpress
ProteomicsComprehensive proteomics analysis of polyhydroxyalkanoate (PHA) biology in Pseudomonas putida KT2440: the outer membrane lipoprotein OprL is a newly identified phasin Dataset 3
Pseudomonas putida KT2440 is an important bioplastic-producing industrial microorganism capable of synthesizing the polymeric carbon-rich storage material, polyhydroxyalkanoate (PHA). PHA is sequestered in discrete PHA granules, or carbonosomes, and accumulates under conditions of stress, for examp...
ORGANISM(S): Pseudomonas putida KT2440 
2024-06-16 | PXD045993 | Pride
Proteomics Pseudomonas putida Bioplastics 
ProteomicsSIN3A Acetylation Complex - Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal
Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we explore the endogenous composition of the Sin3a-Hdac complex in pluripotent embryo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-05-19 | PXD005464 | Pride
Self-renewal Sin3a complex Embryonic stem cell Fam60a 
GenomicsPolycomb-like 3 is a PRC2 component that supports embryonic stem cell self-renewal
Polycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3), which regulates gene expression and controls diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and cancer. Here we show that Polycomb-like 3 (Pcl3) is a component of PRC2 t...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-28325 | biostudies-arrayexpress
GenomicsPolycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
The Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin in order to confer transcriptional silencing during lineage transitions remains unclear. Here...
ORGANISM(S): Mus musculus 
2012-11-17 | E-GEOD-41609 | biostudies-arrayexpress
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