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TranscriptomicsPOU4F1 is associated with t(8;21) AML and contributes directly to its unique transcriptional signature
POU4F1 is associated with t(8;21) acute myeloid leukemia (AML) and contributes directly to its unique transcriptional signature To identify targets of POU4F1, we performed gene expression profiling, comparing Pou4f1+/+ or Pou4f1-/- fetal liver cells to cells overexpressing POU4F1 and identified 140 ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-19997 | biostudies-arrayexpress
TranscriptomicsThe impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells
The extent to which differences in germ line DNA copy number contribute to natural phenotypic variation is unknown. We analyzed the copy number content of the mouse genome to a sub-10 kb resolution. We identified over 1,300 copy number variant regions (CNVRs), most of which are < 10 kb in length, ar...
ORGANISM(S): Mus musculus 
2009-03-08 | E-GEOD-10656 | biostudies-arrayexpress
TranscriptomicsDissecting engineered cell types and enhancing cell fate conversion via CellNet
Engineering clinically relevant cells in vitro holds promise for regenerative medicine, but most protocols fail to faithfully recapitulate target cell properties. To address this, we developed CellNet, a network biology platform that determines whether engineered cells are equivalent to their target...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-59037 | biostudies-arrayexpress
TranscriptomicsDonor cell type influences the epigenome and differentiation potential of human induced pluripotent stem cells
This SuperSeries is composed of the following subset Series: GSE27134: DNA methylation data from human iPS cells, ES cells, cord blood, and keratinocytes GSE27186: Expression data of human somatic cell types and induced pluripotent stem cells GSE31742: DNA methylation data from human keratinocyte-de...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-27224 | biostudies-arrayexpress
TranscriptomicswuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data
Copy number variants (CNVs) are currently defined as genomic sequences that are polymorphic in copy number and range in length from 1,000 to several million base pairs. Among current array-based CNV detection platforms, long-oligonucleotide arrays promise the highest resolution. However, the perfo...
ORGANISM(S): Mus musculus 
2008-03-11 | E-GEOD-10511 | biostudies-arrayexpress
TranscriptomicsA high resolution map of segmental DNA copy number variation in the mouse genome
Submicroscopic (< 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. CNVs have been detected in diverse species, including mice and humans. Published...
ORGANISM(S): Mus musculus 
2006-11-20 | E-GEOD-5805 | biostudies-arrayexpress
TranscriptomicsThe transcriptional landscape of hematopoietic stem cell ontogeny
Transcriptome analysis of adult hematopoietic stem cells (HSC) and their progeny has informed our understanding of blood differentiation and leukemogenesis, but a similarly transformative analysis of the embryonic origins of hematopoiesis is lacking. To address this issue, we acquired gene expressi...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-37000 | biostudies-arrayexpress
TranscriptomicsExpression data of human somatic cell types and induced pluripotent stem cells
Transcription factor-mediated reprogramming yields induced pluripotent stem cells (iPSC) by erasing tissue specific methylation and re-setting DNA methylation status to an embryonic stage. We compared bona fide human iPSC derived from umbilical cord blood (CB) and neonatal keratinocytes (K). Through...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-27186 | biostudies-arrayexpress
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