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ProteomicsHELA whole proteome of carboxypyridostatin (cPDS) treated cells
Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded mitochondrial mRNAs whose protein products ar...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046213 | Pride
Hela Cpds Label-free 
ProteomicsHEK whole proteome of carboxypyridostatin (cPDS) treated cells
Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis. Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which primarily depends on the cytoplasmic translation of nuclear-encoded mitochondrial mRNAs whose protein products a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046236 | Pride
Hek Cpds Label-free 
UnknownNovel CDK-independent function of CDC25 phosphatases in mRNA translation
Not available
S-SCDT-10_1038-S44319-026-00852-Y | biostudies-other
TranscriptomicsHuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA (mRNA)
Upon muscle injury the high mobility group box 1 (HMGB1) protein is up-regulated and secreted to initiate reparative responses. Here we show that HMGB1 controls myogenesis both in vitro and in vivo, during development and after adult muscle injury. HMGB1 expression in muscle cells is regulated at th...
ORGANISM(S): Mus musculus 
2013-08-14 | E-GEOD-49856 | biostudies-arrayexpress
TranscriptomicsHuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA (miRNA)
Upon muscle injury the high mobility group box 1 (HMGB1) protein is up-regulated and secreted to initiate reparative responses. Here we show that HMGB1 controls myogenesis both in vitro and in vivo, during development and after adult muscle injury. HMGB1 expression in muscle cells is regulated at th...
ORGANISM(S): Mus musculus 
2013-08-14 | E-GEOD-49855 | biostudies-arrayexpress
TranscriptomicsDestabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation
HuR promotes myogenesis by stabilizing MyoD, Myogenin and p21 mRNAs during the fusion step of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle promoter nucleophosmin (NPM...
ORGANISM(S): Mus musculus 
2014-04-26 | E-GEOD-57113 | biostudies-arrayexpress
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