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MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
MetabolomicsReal-world neonicotinoid mixture exposure reveals synergistic cytotoxicity and divergent pathway vulnerabilities in human cell lines

In this study, five human cell lines (A2780, Chang liver, HEK293T, HeLa, and HepG2) were used as models and exposed to mixtures of neonicotinoids (NEOs) and their metabolites. The mixture concentrations were prepared based on human biomonitoring data to reflect the actual detected levels of NEOs ...

2026-06-22 | MTBLS13896 | MetaboLights
MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
TranscriptomicsDietary heme induces instantaneous oxidative stress but delayed cytotoxicity and compensatory hyperproliferation in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is compensated by hyperproliferation and hyperplasia of crypt cells, which was induced by a...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-40671 | biostudies-arrayexpress
Metabolomics1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug
1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in combination with multivariate statistical analyses to study the metabolic response of whole cells to the treatment with a hexacationic ruthenium metallaprism [1]6+ as potential anticancer drug. Human ovarian cancer cell...
2015-01-16 | MTBLS156 | MetaboLights
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
ProteomicsEnglerin A rewires phosphosignaling via HSP27 hyperphosphorylation to induce cytotoxicity in renal cancer cells
Englerin A (EA) is a small molecule natural product with selective cytotoxicity against renal cancer cells. EA has been shown to induce apoptosis and cell death through cell cycle arrest and/or insulin signaling pathways. However, its specific biological mode of action or targets in renal cancer rem...
ORGANISM(S): Homo sapiens (Human) 
2022-07-25 | PXD034333 | Pride
Hsp27 Anti-cancer drug Phosphoproteomics Renal cancer Englerin a 
ProteomicsG9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered TCR-T cells against hepatocellular carcinoma
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost...
ORGANISM(S): Homo Sapiens (human) 
2023-01-19 | PXD039542 | JPOST Repository
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