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ProteomicsFBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Eradicating leukemic stem cells (LSCs) and overcoming tyrosine kinase inhibitor (TKI) resistance is urgent for chronic myeloid leukemia (CML) treatment. We find that F-box protein 3 (FBXO3) is highly upregulated in CD34+ CML stem cells from TKI-resistant patients and identify it as an innovative CML...
ORGANISM(S): Homo sapiens (Human) 
2026-01-25 | PXD073522 | Pride
Tkis resistance Fbxo3 Cml-lscs Dusp9 Chronic myeloid leukemia 
UnknownBreeding response of transcript profiling in developing seeds of Brassica napus.
Not available
S-EPMC2697984 | biostudies-literature
ProteomicsCalcium-mediated calreticulin IRE1α interaction drives dynamic fluctuation of IRE1α activity under chronic endoplasmic reticulum stress
To investigate the mechanisms underlying fluctuating IRE1α phosphorylation under chronic endoplasmic reticulum stress, we performed co-immunoprecipitation coupled with mass spectrometry (IP-MS) to identify IRE1α-interacting proteins. Protein complexes were analyzed by LC-MS/MS, followed by bioinform...
ORGANISM(S): Homo Sapiens 
2026-01-30 | PXD073899 |
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.
Not available
S-EPMC11154374 | biostudies-literature
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