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ProteomicsIdentification of PRMT1 interaction proteins in cancer and neural stem cells
We have showed that cancer cells (or tumorigenic cells) resemble neural stem/progenitor cells in regulatory network, tumorigenicity and differentiation potential. We have shown PRMT1 is a protein that is upreguated in and promotes vaious cancers. The expression of its gene is localized to embryonic ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-20 | PXD026851 | Pride
Ne-4c Prmt1 Hepg2 Lc-ms/ms 
ProteomicsIdentification of Setdb1 interaction proteins in neural stem cells
Setdb1 is an epigenetic factors catalyzing modification of H3K9me3. Expression of its gene is localized to embryonic neural cells during vertebrate embryogenesis, suggesting its role in regulating neural stemness. The project is to identify the interaction partners of Setdb1, by which Setdb1 regulat...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD030453 | Pride
Setdb1 Neural stem cell Lc-ms/ms 
UnknownUpregulation of Ying Yang 1 (YY1) suppresses esophageal squamous cell carcinoma development through heme oxygenase-1.
Not available
S-EPMC7656543 | biostudies-literature
ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD047175 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia. 
MetabolomicsTranscriptomics and metabolomics of engineered Synechococcus elongatus during photomixotrophic growth

BACKGROUND: Converting carbon dioxide (CO2) into value-added chemicals using engineered cyanobacteria is a promising strategy to tackle the global warming and energy shortage issues. However, most cyanobacteria are autotrophic and use CO2 as a sole carbon source, which makes it h...

2022-03-21 | MTBLS2825 | MetaboLights
ProteomicsNitric oxide modulates Saccharomyces cerevisiae biofilm formation though regulating the transmembrane protein CTR1 by activating its transcriptional factor MAC1.
Biofilms with immobilized cells in industrial fermentation are beneficial. Encased in extracellular polymeric substance, cells forming biofilms are regulated by various factors. Nitric oxide (NO), as a signaling molecule, recognized as quorum sensing molecule regulating microbe biofilm formation. Re...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-12 | PXD010751 | Pride
Transcription factor mac1 Nitric oxide Saccharomyces cerevisiae Biofilm 
UnknownComparative Transcriptome Profiling Reveals Changes of microRNAs Response to Exercise in Rats with Neuropathic Pain.
Not available
S-EPMC8356008 | biostudies-literature
TranscriptomicsRNA-seq of neuronal SOX2-ablated murine suprachiasmatic nuclei against wild-type littermate controls
Mice lacking the stem/progenitor cell transcription factor, Sex determining region Y-box 2 (SOX2), in neurons of the suprachiasmatic nuclei display imprecise, poorly consolidated behavioral rhythms that do not entrain efficiently to environmental light cycles. RNA sequencing revealed that Sox2 defic...
ORGANISM(S): Mus musculus 
2019-03-18 | E-MTAB-7496 | biostudies-arrayexpress
UnknownImmunogenicity and protective efficacy against murine tuberculosis of a prime-boost regimen with BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein.
Not available
S-EPMC3065234 | biostudies-literature
UnknownTowards development of a high-strength stainless Mg alloy with Al-assisted growth of passive film.
Not available
S-EPMC9529920 | biostudies-literature
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