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GenomicsMicrobiome‐Based Modeling of CAR‐T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing
The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell‐driven cancer immunotherapies. However, clinical studies supporting microbiota‐based interventions in chimeric antigen receptor T‐cell (CAR‐T) therapy remain scarce. This study include...
ORGANISM(S): human gut metagenome 
2026-08-26 | E-MTAB-17540 | biostudies-arrayexpress
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080766 | MassIVE
ProteomicsProteomic analysis reveals enzymes for β-D-glucan formation and degradation in Levilactobacillus brevis TMW 1.2112
Bacterial exopolysaccharide (EPS) formation is crucial for biofilm formation, protection against environmental factors or as storage compounds. EPSs produced by lactic acid bacteria (LAB) are appropriate for applications in food fermentation or the pharmaceutical industry, yet the dynam-ics of forma...
ORGANISM(S): Levilactobacillus brevis 
2022-03-21 | PXD031809 | Pride
Moonlighting proteins Glycosyl hydrolase Β-glucan Exopolysaccharide Levilactobacillus brevis tmw 1.2112 Glycosyltransferase Proteome Secretome 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
MetabolomicsPlasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10-15 yr to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagno...

2023-11-13 | MTBLS1584 | MetaboLights
TranscriptomicsHepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS) [miRNA]
Perfluorooctanesulfonate (PFOS) has been widely used in a variety of industrial and commercial applications as a surfactant and stain repellent. PFOS causes liver damage (including liver tumors) in experimental animals, primarily via interaction with PPARa and CAR/PXR. We investigated the involvemen...
ORGANISM(S): Rattus norvegicus 
2015-08-01 | E-GEOD-69521 | biostudies-arrayexpress
UnknownIntestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO2 phytopharmaceutical preparation.
Not available
S-EPMC5487500 | biostudies-literature
TranscriptomicsThe Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging
Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate pote...
ORGANISM(S): Rattus norvegicus 
2012-07-16 | E-GEOD-34424 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach
Preterm birth (PTB) is a leading global cause of infant mortality. Risk factors include genetics, lifestyle choices and infection. Understanding the mechanism of PTB could aid the development of novel approaches to prevent PTB. This study aimed to investigate the metabolic biomarkers of PTB in early...
2023-05-24 | MTBLS1990 | MetaboLights
ProteomicsCount Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler’s Documents by EVA Technology and Mass Spectrometry
The interest of scientists in analysing items of World Cultural Heritage, has been exponentially increasing since the beginning of the new millennium. These studies have grown considerably in tandem with the development and the use of sophisticated and sensitive technologies such as the high-resolut...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD041350 | Pride
Eva diskettes Ancient proteins Mass spectrometry Vlad the impaler Dracula 
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