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MetabolomicsDeciphering the Anti-Biofilm Mechanism of Anthraquinone-2-Carboxylic Acid Against MRSA by Comprehensive Multi-Omics Analysis

Background: Methicillin-resistant Staphylococcus aureus (MRSA) biofilms exhibit high levels of drug resistance and cause nosocomial infections in humans, thus posing a sustainable global health threat. This underscores the critical need to develop novel antibiofilm therapeutics with high efficacy...

2025-09-18 | MTBLS13012 | MetaboLights
MetabolomicsGermacrone Protects Against DSS Induced Colitis Through a Gut Microbiota Derived Indole-3-Carboxylic Acid-AhR-ILC3/IL-22 Axis
Ulcerative colitis (UC) is a chronic recurrent inflammatory bowel disease, which is characterized by intestinal microbiota dysbiosis, intestinal barrier and mucosal immune dysfunction. Given the limited effect of biological agents for UC, there is an urgent need to develop more effective pharmacolog...
2026-08-30 | MTBLS15475 | MetaboLights
TranscriptomicsTranscription profiling of rat AFTER IN vivo administration OF Gamendazole AND Lonidamine
rat testis time changes; Experimental details are found at Tash et al, Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP-90, eEF1A, and stimulates IL-1 transcription in Sertoli cells, Biol. Reprod. (2007) under review Experiment Overall Design: Adult male r...
ORGANISM(S): Rattus rattus 
2008-04-10 | E-GEOD-8485 | biostudies-arrayexpress
ProteomicsCarboxylic acid consumption and production by Corynebacterium glutamicum_LC-MS/MS
Corynebacterium glutamicum is well-known as an industrial workhorse, most notably for its use in the bulk production of amino acids in the feed and food sector. Fast growth and robustness against oscillatory oxygen availability, which can occur in large-scale bioreactors, are advantageous properties...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2019-03-14 | PXD012760 | Pride
Scale down Carboxylic acid Heterogeneity Oxygen oscillation Corynebacterium glutamicum 
MetabolomicsMetabolomic analysis on Microcystis aeruginosa cells under various amino acid supplementation conditions
Threonine, an essential amino acid for translation, exhibits toxicity towards slow-growing cyanobacteria. This prompted us to perform transcriptomic and proteomic analyses using Microcystis aeruginosa cells treated with threonine, revealing a noteworthy upregulation of thrC, annotated as pyridoxal 5...
2025-04-02 | MTBLS11852 | MetaboLights
GenomicsActivation of Hydroxy-carboxylic Acid Receptor 1 effect on cardiomyocytes
Activation of Hydroxy-carboxylic Acid Receptor 1 effect on cardiomyocytes
PRJNA932761 | ENA
MetabolomicsGut symbiotic bacteria-derived nicotinic acid regulates Bactrocera dorsalis reproduction

Depletion of gut commensal bacteria significantly reduced nicotinic acid (NA) levels in the hemolymph and ovaries of Bactrocera dorsalis, leading to impaired ovarian development. This inhibition was reversed by exogenous NA supplementation. We identified Enterobacter hormaechei as a key NA-produc...

2025-07-30 | MTBLS12798 | MetaboLights
MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
MetabolomicsSerum organic acid metabolites can be used as potential biomarkers to identify prostatitis, benign prostatic hyperplasia, and prostate cancer (Targeted organic acid assay)

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prostat...

2023-04-17 | MTBLS6038 | MetaboLights
ProteomicsProteomics of B16-F10 cells treated by carboxylic acids
To elucidate the mechanisms by which the four carboxylic acids—3-phenyllactic acid, lactic acid, L-pyroglutamic acid, and malic acid—inhibit melanin production in B16-F10 cells, a comparative proteomic analysis was conducted to assess changes in protein expression.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD061919 | Pride
L-pyroglutamic acid 3-phenyllactic acid Lactic acid Malic acid 
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