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MetabolomicsMongolian medicine Wulanwendusu-11 ameliorates myocardial ischemia-reperfusion injury in association with the modulation of intestinal microbiota and associated metabolic pathways

Abstract

Objective: Wulanwendusu-11 (WLWDS-11), a traditional Mongolian medicinal formula, is commonly used for the treatment of Cardiovascular diseases. However, its therapeutic material basis and in vivo metabolic profile in the context of chronic myocardial ischemia-reperfusion injury (M...

2025-11-22 | MTBLS13370 | MetaboLights
MetabolomicsThe dynamic changes and mechanism of no reflow injury after myocardial ischemia-reperfusion
This study aims to investigate the dynamic changes and correlation of no-reflow (NR) injury following myocardial ischemia and reperfusion, and to explore the underlying mechanism of NR injury through transcriptomic and metabolomic analysis. Methods: Healthy male SD rats were divided into two batches...
2026-08-25 | MTBLS15452 | MetaboLights
MetabolomicsIntraoperative intestinal ischemia-reperfusion injury aggravates postoperative delirium by remodeling gut microbiota
Postoperative delirium, is a notable and serious complication after surgery, commonly extending hospitalization by 2-3 days. In a cohort of 167 patients, elevated serum intestinal fatty acid binding protein (I-FABP) was identified as an independent risk factor for postoperative delirium. Complementa...
2026-03-30 | MTBLS14186 | MetaboLights
TranscriptomicsCaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury
Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress
TranscriptomicsDecorin protects cardiac myocytes against simulated ischemia/reperfusion injury
Primary cardiac myocytes isolated from neonatal Wistar rats were cultured and simulated ischemia/reperfusion injury were conducted on them in the presence or absence of decorin. Decorin is a small leucin-rich proteoglycan, which has a cardiocytoprotective effect. The underlaying mechanism of this ca...
ORGANISM(S): Rattus norvegicus 
2020-12-31 | E-MTAB-9325 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat myocardial tissue to investigate the cardioprotective mechanism of baicalin in myocardial ischemia-reperfusion injury
This study aimed to investigate the cardioprotective mechanism of baicalin (BAI) against myocardial ischemia-reperfusion injury (MIRI) in rats. We performed RNA-seq on left ventricular myocardial tissue from three groups: Sham (vehicle control), I/R (ischemia-reperfusion injury model), and I/R+BAI (...
ORGANISM(S): Rattus norvegicus 
2026-07-31 | E-MTAB-17471 | biostudies-arrayexpress
MetabolomicsMetabolomic data related to the alleviation of cardiac ischemia/reperfusion injury by NADPH derived from pentose phosphate pathway

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Exercise (swimming or treadmill)-induced physiological hypertrophy ...

2026-05-14 | MTBLS14272 | MetaboLights
ProteomicsAnalysis of cardiac ischemia-reperfusion injury using DIA proteomics and N-terminomics
Data used in the publication: Analysis of cardiac ischemia-reperfusion injury using DIA proteomics and N-terminomics reveals alterations in mitochondrial function and metabolism
ORGANISM(S): Rattus (ncbitaxon:10114) 
MSV000092906 | MassIVE
MetabolomicsTRIM47 promotes cardiac ischemia/reperfusion injury
This study shows that TRIM47 is upregulated in cardiomyocytes during cardiac I/R injury in an EGR1-dependent manner, correlating with injury severity. Cardiomyocyte-specific TRIM47 overexpression worsens, while TRIM47 knockout alleviates, I/R-induced cardiac injury and dysfunction. Mechanistically, ...
2026-08-28 | MTBLS14676 | MetaboLights
TranscriptomicsDifferential Gene Regulation during murine in vivo heart ischemia comparing wildtype and Per2 deficient mice
Disruption of peripheral circadian rhyme pathways dominantly leads to metabolic disorders. Studies on circadian rhythm proteins in the heart indicated a role for Clock or Per2 in cardiac metabolism. In fact, Per2-/- mice have larger infarct sizes with a deficient lactate production during myocardial...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-45818 | biostudies-arrayexpress
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