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Proteomicsroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
Myosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-binding protein C (cMyBP-C, encoded by MYBPC3). Here, we have ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-02 | PXD076207 | Pride
Hypertrophic cardiomyopathy Myosin inhibition 
MetabolomicsACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation
Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...
2026-04-15 | MTBLS14207 | MetaboLights
ProteomicsIdentification of cardiac myosin heavy chain post-translational modifications in hibernating grizzly bears
Mammal hibernation is a physiological process with unclear molecular mechanisms. Here, we aimed to investigate whether cardiac myosin heavy chain post-translational modifications would be affected by hibernation. For that, we used cardiac left ventricle specimens from active and hibernating adult gr...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2025-05-07 | PXD054499 | Pride
Bear Ptm Myosin 
ProteomicsUnusual cardiac myosin heavy chain post-translational modifications with systolic heart failure
In the present study, we aimed at defining whether cardiac myosin heavy chain (MYH7) post-translational modifications would be altered in systolic heart failure. For that, we had access to septal tissue from donors and from patients with non-genetic dilated cardiomyopathy or with ischemic cardiomyop...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076695 | Pride
Heart failure  systolic dysfunction  myh7  myosin 
ProteomicsCardiomyocyte external mechanical unloading activates modifications of alpha-actinin differently from sarcomere-originated unloading
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein compares the sarcomeric assembly and disassembly processes in heart cells by imposing mechano-signa...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-05 | MSV000091010 | MassIVE
ProteomicsMavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation
Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin that drives contraction. Therapeutic intervention for hypertrophic cardiomyopathy has until recentl...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-03-26 | PXD059316 | Pride
Dsbu Skyline Cardiac myosin Quantitative crosslinking ms 
ProteomicsIdentification of phosphorylation and other post-translational modifications in the central C4-C5 domains of murine cardiac myosin binding protein C
Cardiac myosin binding protein C (cMyBPC) is a critical multidomain protein that modulates myosin cross bridge behavior and cardiac contractility. cMyBPC is principally regulated by phosphorylation of the residues within the M-domain of its N-terminus. However, not much is known about the phosphoryl...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD031262 | Pride
Post translational modification Cardiac myosin binding protein c Mass spectrometry 
GenomicsAmino terminus of cardiac myosin binding protein-C regulates cardiac contractility
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility
PRJNA716300 | ENA
TranscriptomicsAtrial Myxomas Arise From Multipotent Myxoid Cardiac Stem Cells
Myxomas, the most common primary tumor of the heart, usually develop in the atria and consist of a myxoid matrix composed of an acid-mucopolysaccharide-rich stroma with polygonal stromal cells scattered throughout the matrix. These benign tumors, despite their rarity, are a research focus because of...
ORGANISM(S): Homo sapiens 
2020-05-02 | E-MTAB-8642 | biostudies-arrayexpress
TranscriptomicsAtrial Myxomas Arise From Multipotent Myxoid Cardiac Stem Cells
Myxomas, the most common primary tumor of the heart, usually develop in the atria and consist of a myxoid matrix composed of an acid-mucopolysaccharide-rich stroma with polygonal stromal cells scattered throughout the matrix. These benign tumors, despite their rarity, are a research focus because of...
ORGANISM(S): Homo sapiens 
2020-04-01 | E-MTAB-8701 | biostudies-arrayexpress
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