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MetabolomicsActivation of imprinted gene Pw1 promotes cardiac fibrosis after ischemic injury

Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition in the myocardium, is a critical target for heart disease treatments. Pw1 (paternally expressed gene 3) is an imprinted gene expressed from the paternally allele, and de novo purine biosynthesis (DNPB) is a crucial...

2024-12-03 | MTBLS11364 | MetaboLights
MetabolomicsUrinary metabolomics reveals kynurenine pathway perturbation in newborns with transposition of great arteries after surgical repair

INTRODUCTION: Transposition of the great arteries (TGA) is a cyanotic congenital heart defect that requires surgical correction, with the use of cardiopulmonary-bypass (CPB), usually within 3 weeks of life. The use of CPB in open heart surgery results in brain hypoperfu...

2020-04-15 | MTBLS946 | MetaboLights
MetabolomicsAnalysis of human urine reveals metabolic changes related to the development of acute kidney injury following cardiac surgery
In an effort to identify novel biomarkers capable of predicting the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB) use, urine specimens were collected before and at 4 and 24 hours after surgery from 106 patients and analyzed by means of nuclear magne...
2012-10-21 | MTBLS24 | MetaboLights
TranscriptomicsCardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment. Loosely defined based on their mesenchymal origin, capacity to adhere to plastic and to secrete extracellular matrix, cardiac fibroblasts have been largely neglected due to hetero...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50531 | biostudies-arrayexpress
TranscriptomicsAnalysis of cardiac gene expression in response to isoproterenol-induced heart failure (part 1)
Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to ind...
ORGANISM(S): Mus musculus 
2010-05-31 | E-GEOD-16243 | biostudies-arrayexpress
TranscriptomicsAnalysis of cardiac gene expression in response to isoproterenol-induced heart failure (part 2)
Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to ind...
ORGANISM(S): Mus musculus 
2010-05-31 | E-GEOD-16246 | biostudies-arrayexpress
TranscriptomicsGenomeâ??wide transcriptional profiling with spatial resolution identifies Bone Morphogenetic Protein signaling as essential regulator of zebrafish cardiomyocyte regeneration.
In contrast to mammals, zebrafish regenerate heart injuries via proliferation of cardiomyocytes located at the wound border. Here, we show that tomo-seq can be used to identify whole-genome transcriptional profiles of the injury zone, the border zone and the healthy myocardium. Interestingly, the bo...
ORGANISM(S): Danio rerio 
2016-01-11 | E-GEOD-74652 | biostudies-arrayexpress
ProteomicsiPSC nanovesicles cardiac cell repair
Here, we engineered functional EV-like nanovesicles (NVs) from human-induced pluripotent stem cells and highlight their potential as a functional surrogate for natural EVs for tissue repair. Proteome profiling of target cells further identified pathways implicated in angiogenesis (MYH10, AAMP, SLC3A...
ORGANISM(S): Homo sapiens (Human) 
2023-01-15 | PXD036654 | Pride
Proteomics Ipsc Nanovesicles Cardiac repair Cell reprogramming 
ProteomicsCDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway
SGK3 (threonine-protein kinase 3) is a functional kinase we identified previously with the capacity to promote cardiomyocyte proliferation and cardiac repair after myocardial infarction. However, the upstream signals regulating SGK3 are still unknown. Based on the quantitative proteomics data and pu...
ORGANISM(S): Mus Musculus 
PXD035187 |
TranscriptomicsTranscription profiling of lung tissue from transcription-coupled repair-deficient (Csb-/-) and wild type mice in response to ozone
We investigated whether transcription-coupled repair deficient mice (Cockayne syndrome B knockout mice (Csb-/-)), known to be sensitive to oxidative stressors, have a different response to ozone than its repair-proficient control, Csb heterozygote (Csb+/-) mice.
ORGANISM(S): Mus musculus 
2006-11-13 | E-TABM-137 | biostudies-arrayexpress
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