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ProteomicsSequential Fractionation Strategy Identifies Nine Missing Proteins in The Mitochondrial Proteome of Commonly Used Cell Lines
Identification of mitochondrial proteins with a bottom up approach after organelle enrichment and 1D PAGE separation for 5 different cell lines. The bands were cut and the proteins reduced, alkylated and digested with trypsin according to a conventional protocol. Acquisition were performed on the Or...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-05-28 | MSV000082409 | MassIVE
ProteomicsCOVID-19 PATIENTS WITH NEUROLOGICAL SYMPTOMS PRESENT BROAD CENTRAL NERVOUS SYSTEM MOLECULAR AND STRUCTURAL ALTERATIONS ASSOCIATED WITH SYSTEMIC INFLAMMATION AND DISEASE SEVERITY
Background. COVID-19-induced neurological disease is a growing concern. Here we provide a comprehensive clinical, molecular, and neuroimaging investigation of patients presenting neurological symptoms to investigate underlying processes. Methods. We performed a detailed systematized clinical, labor...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD033979 | Pride
Cerebrospinal fluid Csf Inflammation Prorteomics Covid-19 
ProteomicsSARS-CoV-2 induced glycolysis is essential for monocytes inflammatory response
We have analyzed through shotgun proteomics approach Macrophages and Monocytes infected by the virus Sars-Cov 2, performing a qualitative and quantitative analysis.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019157 | Pride
Covid-19 Sars-cov2 Proteomics 
ProteomicsSARS-CoV-2 Infection Impacts Glutamate/Glutamine Metabolism in Syrian Hamster Central Nervous System
Coronaviruses belong to a well-known family of enveloped RNA viruses and the causative agent of the common cold. Although the seasonal coronaviruses do not pose a threat to human life, three members of this family, i.e., SARS-CoV, MERS-CoV and recently, SARS-CoV2, may cause severe acute respiratory ...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2022-09-28 | PXD029426 | Pride
Sars-cov2 Proteomics Glutamine Neuropathology Covid-19 
ProteomicsPathogenesis of chikungunya virus infection associated with fatal outcome
Chikungunya virus (CHIKV) is a mosquito-borne virus that causes acute, subacute, and chronic human diseases and can cause neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomics, proteomics, and genomic analy...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043815 | Pride
Chikungunya infection Plasma proteomics Immune response 
ProteomicsSARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability
COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety and cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms and are associated with altered cerebral cortical thickness. Using an independent cohort...
ORGANISM(S): Homo sapiens (Human) 
2022-09-01 | PXD023781 | Pride
Covid-19 Astrocytes Proteomics Sars-cov2 
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