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ProteomicsHuman Diffuse large B cell lymphoma cell lines
We have analyzed by label free mass spectrometry the whole cells and secreted extracellular vesicles (EVs) proteomes of two different molecular subtypes of DLBCL, germinal center B cell (GCB subtype) and activated B cell (ABC subtype). Cell line: OCI-Ly3 (ABC) O3_2.raw O3_1.raw O2_2.raw O2_1.raw O...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028267 | Pride
Human Cancer Diffuse large b cell lymphoma cell lines Extra cellular vesicles 
TranscriptomicsHigh-resolution genomic profiling of marginal zone B-cell lymphomas and variants
We studied marginal zone B-cell lymphomas of the gastrointestinal tract including seven small cell MALT lymphomas, eight composite lymphomas and thirteen large cell variants using SNP-array profiling. We found an increase of genomic complexity with lymphoma progression, and could identify gains of p...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-36311 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation profiling of human HeLa cells after immunoprecipitation of ptb65 associated mRNAs
PTB is multifunctional RNA binding protein reported to be involved in splicing, 3' -end processing, stability and translational regulation. Sample preparation methods (Gama-Carvalho et al, 2006, submitted); Suspension HeLa cells were grown in DMEM, 10% FCS, Pen/Strep and split 1:2 the day before har...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6021 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of HeLa cells after immunoprecipitation of U2AF65 associated mRNAs
U2AF65 is an essential splicing factor involved in the 3'splice site recognition dureing the first steps of spliceosome assembly. In addition, this protein has nucleocytoplasmic shuttling activity and the Drosophila homologue has been implicated in mRNA export. We have used microarray hybridization ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6022 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics for triaging of cytochrome b inhibitors during Chagas’ disease drug discovery

Chagas’ disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is a potentially fatal condition for which new treatments are urgently needed. Due to the lack of validated drug targets, phenotypic screening followed by target deconvolution is the dominant approach in Chagas’ d...

2026-01-12 | MTBLS13510 | MetaboLights
UnknownNFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytes.
Not available
S-EPMC5004684 | biostudies-literature
TranscriptomicsSynergy between PI3K Signaling and MYC in Burkitt Lymphomagenesis
In Burkitt lymphoma (BL), an aggressive germinal-center (GC) derived non-Hodgkin B-cell lymphoma characterized by MYC translocations as early transforming event, the apoptotic properties of MYC must have been overcome by pro-survival signals. Whereas activation of the pro-survival factor NFkappaB is...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-35219 | biostudies-arrayexpress
ProteomicsPlasma extracellular vesicle proteome identifies diffuse large B cell lymphoma patients
The aggressive B cell lymphoma diffuse large B cell lymphoma (DLBCL) is a heterogeneous entity that requires more precise monitoring and prognosis molecular tools. Extracellular vesicles that are secreted by all cell types are currently recognized as serving as a proxy for the cell of origin. Utili...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036735 | Pride
Cancer Extracellular vesicles Diagnostic Liquid biopsy Plasma 
UnknownGenotyping of paired KPC-producing Klebsiella pneumoniae isolates with and without divergent polymyxin B susceptibility profiles.
Not available
S-EPMC8578263 | biostudies-literature
TranscriptomicsBovine trophoblasts: control vs. infected with Brucella abortus
Brucellosis is still a widespread zoonotic disease. Very little is known about the interaction between B. abortus and trophoblastic cells, which is essential for better understanding the pathogenesis of the Brucella-induced placentitis and abortion, a key event for transmission of the disease. The g...
ORGANISM(S): Bos taurus 
2010-05-26 | E-GEOD-10342 | biostudies-arrayexpress
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