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ProteomicsMapping the spatial proteome of metastatic cells in colorectal cancer
Here, we aimed to study metastasis mechanisms using spatial proteomics applied to the KM12 cell model of metastasis. KM12 cells were metabolically labelled using SILAC. SILAC has been successfully used for the analysis of proteome turnover and for the identification of changes in proteome localizati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-23 | MSV000088431 | MassIVE
ProteomicsCirculating endoglin induces hypertension via the upregulated expression of BMP4
Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and involved in cardiovascular diseases. Upon the proteolytic processing of the membrane-bound protein, a circulating form of endoglin (soluble endoglin, sEng) can be released, and high levels of sEng have been obser...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD016228 | Pride
Tgf-β Endothelial cells Preeclampsia Hypertension Endoglin Hht Bmp4 
ProteomicsDevelopment and validation of a secretome-specific prognostic and predictive gene expression signature for colorectal cancer
Relapse and metastatic progression is a frequent event in colorectal cancer patients detected at early stages. The risk of recurrence requires the development of new biomarkers to correctly predict biological behavior of early stage II and stage III patients and their response to adjuvant chemothera...
ORGANISM(S): Homo sapiens (Human) 
2022-12-27 | PXD032899 | Pride
Prognostic signature Stage stratification Secreted proteins Colorectal cancer Metastasis 
ProteomicsProteomic characterization of transcription and splicing factors associated with a more invasive phenotype in colorectal cancer
To find new transcription and splicing factors associated with the metastatic phenotype we used a concatenated tandem array of consensus transcription factors response elements (catTFRE) on nuclear extracts of colon cancer cell lines. We used two different isogenic pairs of colorectal metastatic cel...
ORGANISM(S): Homo sapiens (Human) 
2017-11-15 | PXD006662 | Pride
Human Lc-msms Transcription Colon cancer Splicing Cell lines Metastasis 
UnknownSnail1 expression is required for sarcomagenesis.
Not available
S-EPMC4198692 | biostudies-literature
Proteomics,MultiomicsChr16-HPP.Pilot experiment.JPR HPP Special issue
"The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To characterize t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083968 | MassIVE
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. MCF7 Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083962 | MassIVE
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. CCD18 Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083961 | MassIVE
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. Ramos Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083967 | MassIVE
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. Jurkat Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083966 | MassIVE
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