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ProteomicsSystem-wide profiling of protein-RNA interactions in sindbis infected cells reveals host regulators of infection
RNA viruses rely on cellular RNA-binding proteins (RBPs) to infect the host cell. However, the repertoire of the cellular RBPs exploited by viruses is largely unknown. Using the ‘RNA interactome capture’ method, we profiled in a proteome-wide scale the RBP-RNA interactions occurring during sindbis v...
ORGANISM(S): Homo sapiens (Human) Sindbis virus 
2019-02-28 | PXD009789 | Pride
Human Lc-msms Sindbis virus 
ProteomicsMulti-level proteomics profiling of virus-restrictive and -permissive cellular environments reveal novel regulators of virus infection
Virus proliferation inside host cells relies on a diverse range of host machineries and is also restricted by the host through expressions of antiviral factors. The configuration of virus-dependency and antiviral factors determine the permissiveness of host cells to virus infection, however, overall...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD052223 | Pride
Human Innate immunity Lc-msms Hek293 cell line Proteomics Silac Phosphoproteomics Hek293t cell line 
ProteomicsAlphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles
RNA is a central molecule for RNA viruses, acting as mRNA and genome. However, the interactions that viral (v)RNA establishes with the host cell is only starting to be elucidated. Here, we determine with unprecedented depth the composition of the ribonucleoproteins (RNPs) of the prototypical arthrop...
ORGANISM(S): Homo sapiens (Human) 
2024-12-19 | PXD029492 | Pride
Rna-binding proteins Vric 
ProteomicsAssembly of cellular proteins with the HIV-1 genome into viral particles regulate virus production and infectivity
The initial steps of the human immunodeficiency virus 1 (HIV-1) lifecycle are regulated by cellular RNA-binding proteins (RBPs). However, the scope of these early host-virus interactions remain largely uncharecterised. To fill this gap, we developed in virion RNA interactome capture (ivRIC) to profi...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2026-05-25 | PXD042829 | Pride
Hiv  rna  rna-binding protein  virus infection  virion  viral particle  rev  rna-interactome capture  pura  purb 
ProteomicsRNA binding regulation is a new dimension in the type I IFN response
The type I interferon (IFN-I) response shapes the intracellular environment to supress virus infection. Historically, this remodelling has been linked to the transcriptional induction of interferon stimulated genes (ISGs). However, IFN-I-driven post-translational regulation of proteins already prese...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD064360 | Pride
Host-virus interactions Rna Interferon Phosphorylation Antiviral factors Phosphoproteomics Rna-binding protein Rna interactome Rbp 
ProteomicsGlobal analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control SARS-CoV-2 infection remains largely unknown. Here, we employ a multi-omic approach to identify systematically ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023418 | Pride
Wcp Cric Sars-cov-2 Calu-3 Vric 
OtherInsights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Data from ProteomeXchange, PXD ID: PXD002880. Experiment: KS_A4_3, file: folder summary. Published as part of Cell. 2012 Jun 8;149(6):1393-406 . From the Abstract: {{i}} RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV cro...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM11210041750 | GPMDB
Resource Reanalysis 
ProteomicsSINV-nsP3 mScarelt-tagged immunoprecipitation
1x107 cells HEK293 FLP-IN T-REX cells were infected with SINVnsP3-mScarlet (bait) or SINVwt (negative control) at 1 MOI. After 18 hours, cells were scrapped and spin down at 300 g 4°C for 10 mins. After the centrifugation, supernatants were discarded and cell pellet washed once with 1X PBS, followed...
ORGANISM(S): Homo sapiens (Human) 
2024-12-19 | PXD054117 | Pride
Sinv-nsp3 
ProteomicsWolbachia strains differ in arbovirus inhibition mechanisms in Aedes mosquitoes
Some strains of the inherited bacterium Wolbachia have been shown to be effective at reducing the transmission of dengue and other positive-sense RNA viruses by Aedes aegypti in both laboratory and field settings and are being deployed for dengue control. The degree of virus inhibition varies betwee...
ORGANISM(S): Aedes Aegypti (ncbitaxon:7159) Wolbachia (ncbitaxon:953) 
2023-06-07 | MSV000092124 | MassIVE
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