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Mitotic entry is triggered by the Cyclin B-Cdk1 kinase, which phosphorylates numer-ous substrates. The accumulation of these phosphorylated substrates relies on inhib-iting the opposing PP2A-B55 phosphatase. With its asynchronous cell divisions, the C. elegans embryo is an attractive model for disse...
ORGANISM(S): Caenorhabditis elegans 
2025-05-07 | PXD054396 | Pride
Heat stress is one of the most prominent and deleterious environmental threads affecting plant growth and development. Upon high temperatures, plants launch specialized gene expression programs that promote stress protection and survival. These programs involve global and specific changes at the tra...
ORGANISM(S): Arabidopsis thaliana 
The brain vasculature is tightly regulated to control the exchange of substances between the periphery and the brain parenchyma at an interface called the blood-brain barrier (BBB). Astrocytes are glial cells that wrap the brain vasculature with a specialised structure called the endfoot, which is a...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-11 | PXD056232 | Pride
Cerebral vasculature is critical in maintaining brain health, as its dysfunction is linked to various neurological illnesses including dementia and stroke. Proteomic studies are integral in understanding the biological mechanism underlying this dysfunction, identifying potential therapeutic targets ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD055837 | Pride
Regulation of gene expression by microRNAs (miRNAs) is essential for normal development, but the roles of miRNAs in the physiology of adult animals are poorly understood. We have isolated a conditional allele of DGCR8/pash-1, which allows reversible and rapid inactivation of miRNA synthesis in vivo ...
ORGANISM(S): Caenorhabditis elegans 
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