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MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
ProteomicsCathepsin B MSP-MS at pH 4.6 and 7.2 without inhibitor
MSP-MS of Cathepsin B at pH 4.6 and pH 7.2 without inhibitor
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086449 | MassIVE
ProteomicsCathepsin B MSP-MS at pH 4.6 and pH 7.2
MSP-MS of Cathepsin B protease at acidic and neutral pH
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086447 | MassIVE
TranscriptomicsTranscription profiling of mouse expressing human Cathepsin L inhibitor hurpin, skin alterations and increased carcinogenesis.
Aim of this study was to identify gene expression differences in the skin of hurpin (=headpin=serpinB13) transgenic mice in comparison to wildtype mice. Experiment Overall Design: Comparison of 4 transgenic mice with 3 wildtype mice. One wildtye sample was used two times. Experiment Overall Design:...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5236 | biostudies-arrayexpress
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
ProteomicsCathepsin B and Cathepsin Z tumor secretome of murine breast cancers
MS-based proteomics study of the cancer secretome and tumor interstitial fluid of tumor cell/macrophage co-cultures and breast tumors in cells and mice lacking both cathepsin B and cathepsin Z
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015209 | Pride
Tumor interstitial fluid Ccm Mouse Secretome 
ProteomicsPotent anti-SARS-CoV-2 activity by the natural product gallinamide A and analogues via inhibition of cathepsin L
The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a key host cysteine protease utilized b...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027300 | Pride
Mrc5 Sars-cov-2 Covid Cathepsin l Veroe6 Gallinamide a Hek293 
TranscriptomicsBovine adult versus prepubertal cumulus cells
The present study was undertaken to discover molecular markers in bovine cumulus cells predictive of oocyte competence and elucidate their functional significance. Differences in RNA transcript abundance in cumulus cells harvested from oocytes of adult versus prepubertal animals (model of poor oocy...
ORGANISM(S): Bos taurus 
2010-05-25 | E-GEOD-10819 | biostudies-arrayexpress
TranscriptomicsCathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic and degenerative disease in humans. Here, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and a...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-79508 | biostudies-arrayexpress
ProteomicsInhibition of cathepsin B and SAPC secreted by HIV-infected macrophages reverse common and unique apoptosis pathways
Human immunodeficiency virus 1 (HIV-1) infects blood monocytes that cross the blood-brain barrier to the central nervous system inducing neuronal damage. This damage is prompted by the secretion of viral and neurotoxic factors by HIV-infected macrophages and can result in HIV associated neurocogniti...
ORGANISM(S): Homo sapiens (Human) 
2022-01-20 | PXD024636 | Pride
Hiv-1 Cathepsin b Tmt Sapc Apoptosis Hand 
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