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Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity determining P1 pocket, was calling for innovative approaches. Proteomic analysis of cell lysates with human cathepsins K, V, B, L, S, and F identified 30,000 cl...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD041185 | Pride
N-terminal COFRADIC analysis of cathespine K, L and S to obtain the substrate specificity profile of these cysteine cathepsins.
ORGANISM(S): Homo sapiens (Human) 
2015-02-10 | PXD001536 | Pride
The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids
Identification of protease substrates and determination of their specificities can provide important insights into their function. In the past decade, several proteomic approaches for identification of protease cleavage sites were developed, each relying on various strategies for peptide labelling a...
ORGANISM(S): Homo sapiens (Human) 
2015-02-10 | PXD001553 | Pride
Multiplex Substrate Profiling by Mass Spectrometry (MSP-MS) of recombinant human cathepsins A-D.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2026-01-06 | MSV000100387 | MassIVE
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