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ProteomicsiMixPro: intelligent Mixing of Proteomes for elimination of false positives in affinity purification-mass spectrometry
Protein complexes are essential in most organizational and functional aspects of the cell. Different strategies currently exist to analyze such protein complexes by mass spectrometry, including affinity purification (AP-MS) and proximal labeling based strategies. However, the high sensitivity of cur...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD004246 | Pride
Human overexpression cell lines ap-ms silac 
ProteomicsProteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity determining P1 pocket, was calling for innovative approaches. Proteomic analysis of cell lysates with human cathepsins K, V, B, L, S, and F identified 30,000 cl...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD041185 | Pride
Imixpro Cofradic N-terminomics Cathepsins 
ProteomicsProteomics exploiting modular baits with different subcellular locations reveal hydrogen peroxide-inducible clone 5 protein (HIC-5) and a glucocorticoid receptor variant as novel testin partners
The LIM domain and tumour suppressor protein Testin (Tes) is downregulated in a variety of human tumours and tumour cell lines. Depending on its conformation, Tes localises to stress fibres and focal adhesions where it forms protein complexes with other members of the actin c...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005058 | Pride
Imixpro Ip Proteomics Hic-5 Testin Gr Lc-ms/ms 
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