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ProteomicsNanobodies as novel tools to monitor the mitochondrial fission factor Drp1
In cells, mitochondria undergo constant fusion and fission. An essential factor for fission is the mammalian dynamin-related protein 1 (Drp1). Dysregulation of Drp1 has been linked to neurodegenerative diseases including Parkinson’s as well as cardiovascular diseases and cancer. Here, we developed n...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD051737 | Pride
Pulldown Proteomics Mitochondrial fission Drp1 Nanobodies 
ProteomicsProteome dynamics in iPSC-derived human dopaminergic neurons – part 2: protein turnover dynamics using SILAC
Dopaminergic neurons participate in fundamental physiological processes and are the cell type primarily affected in Parkinson’s disease (PD). Their analysis is challenging due to the intricate nature of their function, their involvement in diverse neurological processes, their heterogeneity and loca...
ORGANISM(S): Homo sapiens (Human) 
2024-09-12 | PXD051015 | Pride
Proteomics Ipsc Axon Dopaminergic neurons Protein turnover 
ProteomicsProteome dynamics in iPSC-derived human dopaminergic neurons – part 3: dynamic SILAC to study local synthesis and trafficking of proteins
Dopaminergic neurons participate in fundamental physiological processes and are the cell type primarily affected in Parkinson’s disease (PD). Their analysis is challenging due to the intricate nature of their function, their involvement in diverse neurological processes, their heterogeneity and loca...
ORGANISM(S): Homo sapiens (Human) 
2024-09-12 | PXD051016 | Pride
Proteomics Ipsc Axon Dopaminergic neurons Protein turnover 
ProteomicsProteome dynamics in iPSC-derived human dopaminergic neurons – part 1: comprehensive coverage of the proteome using DIA
Dopaminergic neurons participate in fundamental physiological processes and are the cell type primarily affected in Parkinson’s disease (PD). Their analysis is challenging due to the intricate nature of their function, their involvement in diverse neurological processes, their heterogeneity and loca...
ORGANISM(S): Homo sapiens (Human) 
2024-09-12 | PXD050991 | Pride
Proteomics Dia Ipsc Axon Dopaminergic neurons Protein turnover 
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