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ProteomicsStreptavidin biotin-CCW16 pulldown to determine CCW16-modified proteins in HeLa lysate
The SUMO-targeted E3 ubiquitin ligase RNF4 plays an important role in safeguarding genome and proteome integrity. RNF4 recognizes polySUMO modified proteins and induces their proteolytic or non-proteolytic ubiquitylation. Based on the key functions of RNF4 maintaining proteome and genome stability, ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD056954 | Pride
Ccw16 Targets Hela Lfq Rnf4 
ProteomicsWhole cell proteome of HeLa Flp in T-RexTM RNF4 WT treated with either CCW16, 1a or 2c
The SUMO-targeted E3 ubiquitin ligase RNF4 plays an important role in safeguarding genome and proteome integrity. RNF4 recognizes polySUMO modified proteins and induces their proteolytic or non-proteolytic ubiquitylation. Based on the key functions of RNF4 maintaining proteome and genome stability, ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD056951 | Pride
Rnf4 Tmt Wcp Ccw16 Mammalian cells 
UnknownCysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death.
Not available
S-EPMC12635392 | biostudies-literature
UnknownCysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death
Not available
S-SCDT-10_1038-S44319-025-00593-4 | biostudies-other
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