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ProteomicsCD98hc is a target for brain delivery of biotherapeutics
Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3A2) of heterodimeric amino acid transporters (TV^CD98hc). T...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD044159 | Pride
Cns drug delivery Cd98hc Biodistribution Protein engineering Blood-brain barrier 
GenomicsATV-TfR and ATV-CD98hc biodistribution in the mouse brain
ATV-TfR and ATV-CD98hc biodistribution in the mouse brain
PRJNA1091717 | ENA
GenomicsExpression data from CD98hc null and wild type fibroblasts derived from embryonic stem cells
Expression data from CD98hc null and wild type fibroblasts derived from embryonic stem cells
PRJNA523249 | ENA
UnknownCD98hc (SLC3A2) mediates integrin signaling.
Not available
S-EPMC544283 | biostudies-literature
TranscriptomicsATV-TfR and ATV-CD98hc biodistribution in the mouse brain
We evaluated the distributions of transferrin receptor (TfR)- and CD98 heavy chain (CD98hc)-targeting antibody transport vehicles (ATVs) in mouse brain using systemically injected fluorescently tagged ATVs. Combining FACS sorting with scRNA-seq, we report the localization of ATV-TfR and ATV-CD98hc o...
ORGANISM(S): Mus musculus 
2024-10-02 | GSE262436 | GEO
TranscriptomicsExpression data from CD98hc null and wild type fibroblasts derived from embryonic stem cells
CD98 is a heterodimeric protein comprising heavy (CD98hc) and light chains (LAT1, LAT2, xCT, y+LAT1, y+LAT2 and asc1) that confer substrate specificity to the amino acid exchanger. CD98hc-associated transporters have two well stablished biochemical functions: They are able to promote integrin-depend...
ORGANISM(S): Mus musculus 
2019-10-02 | GSE126781 | GEO
UnknownCD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior.
Not available
S-EPMC3879186 | biostudies-literature
UnknownCD98hc facilitates B cell proliferation and adaptive humoral immunity.
Not available
S-EPMC2672195 | biostudies-literature
UnknownCD98hc is a target for brain delivery of biotherapeutics.
Not available
S-EPMC10439950 | biostudies-literature
UnknownCD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling.
Not available
S-EPMC2064475 | biostudies-literature
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