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TranscriptomicsTranscription profiling of human aortic biopsy samples having differing degrees of stiffness
BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-420 | biostudies-arrayexpress
ProteomicsTumor matrix stiffness induces CCN1/CYR61 upregulation of N-Cadherin to promote cancer cell trans-endothelial migration and metastasis
Tumor progression is often accompanied with increased extracellular matrix stiffness, but how this affects endothelial cells (ECs) is largely unknown. We used mass spectrometry to analyse the proteomic changes of primary human ECs cultured on physiological or tumor stiffness and found that CCN1/CYR6...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD003316 | Pride
Stiffness  protome  silac  ccn1  matrigel  huvec  tumour  vasculature 
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
TranscriptomicsInfluence of substrate stiffness on barrier function in an iPSC-derived in vitro blood-brain barrier model
Induced pluripotent stem cells were differentiated to brain microvascular endothelial-like (BMEC-like) cells and cultured on hydrogel substrates of varying stiffness. Cellular changes were measured by bulk transcriptome and proteome readouts.
ORGANISM(S): Homo sapiens 
2021-04-07 | E-MTAB-10336 | biostudies-arrayexpress
TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
GenomicsMechanical Stiffness Controls Dendritic Cell Metabolism and Function
Mechanical Stiffness Controls Dendritic Cell Metabolism and Function
PRJNA680482 | ENA
GenomicsMatrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing
Matrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing
PRJNA1476708 | ENA
ProteomicsThe proteomics data for Increased matrix stiffness promotes fibrogenesis of hepatic stellate cells through AP-1-induced chromatin priming
Matrix stiffness has significant effects on cell behavior, however, less is known regarding the epigenomic and transcriptional regulation underling the effect of matrix stiffness on cells. In this study, we use an in vitro system to assess the phenotypic shifts of hepatic stellate cells (HSCs) follo...
ORGANISM(S): Homo Sapiens 
2025-04-19 | PXD063173 |
TranscriptomicsRNA-seq of human skin fibroblasts from healthy and systemic sclerosis patients with varying matrix stiffness
This study explores how increased matrix stiffness alters fibroblast transcription and its impact on the lineage specification of fibroblast subpopulations in fibrotic skin. Fibroblasts from healthy and systemic sclerosis patients were cultured in a collagen I-based 3D system with varying matrix sti...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-14804 | biostudies-arrayexpress
ProteomicsIQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2
Drivers of therapeutic resistance in cancer include evolution of tumor cell heterogeneity and the tumor microenvironment (TME). Here, we found that increased matrix stiffness promotes radioresistance in glioblastoma (GBM) and maintains the tumor cell hierarchy. Differential gene expression revealed ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-11 | PXD072725 | Pride
Cancer stem cell Glioma stem cell Glioblastoma Radiation Matrix stiffness Iqgap3 Sox2 
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