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MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
MetabolomicsUniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response
Not available
ORGANISM(S): Homo sapiens 
ST000465 | MetabolomicsWorkbench
TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azid...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-07-20 | PXD040084 | Pride
Submitter keyword: lc-msms Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Pdac Pancreatic cancer Extracellular matrix 
ProteomicsA Cell-Permeable Photosensitizer for Selective Proximity Labeling and Crosslinking of Aggregated Proteome
Intracellular proteome aggregation is a ubiquitous disease hallmark with its composition associated with pathogenicity. Herein, we report on a cell-permeable photosensitizer (P8, Rose Bengal derivative) for selective photo-induced proximity labeling, crosslinking and identification of cellular aggre...
ORGANISM(S): Homo Sapiens 
PXD044948 |
GenomicsSingle-cell RNAseq data from mouse ON direction-selective ganglion cells
Single-cell RNAseq data from mouse ON direction-selective ganglion cells
PRJNA869926 | ENA
GenomicsSelective Mediator-dependence of cell type-specifying transcription [HiChIP]
Selective Mediator-dependence of cell type-specifying transcription [HiChIP]
PRJNA579928 | ENA
GenomicsFXR isoform selective effects on hepatoma cell line HepG2
FXR isoform selective effects on hepatoma cell line HepG2
PRJNA552265 | ENA
GenomicsSelective CAR-T cell mediated B cell depletion suppresses interferon signature in SLE [PBMC]
Selective CAR-T cell mediated B cell depletion suppresses interferon signature in SLE [PBMC]
PRJNA1100404 | ENA
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