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ProteomicsA Molecular Glue of RBM39 and DCAF15 Arrests Cell Cycle Progression by Downregulation of CEP192
RBM39 is a crucial component of the spliceosome that is critical for the integrity of mature mRNA, while depletion of RBM39 by Indisulam significantly increases RNA splicing defects. The antitumor activity of Indisulam is partially attributed to its inhibitory effects on cell cycle progression. To i...
ORGANISM(S): Homo sapiens (Human) 
2025-03-20 | PXD056341 | Pride
Rbm39 Cep192 Indisulam Proteomics analysis Cell cycle arrest 
UnknownRecruitment of PP1 to the centrosomal scaffold protein CEP192.
Not available
S-EPMC7888556 | biostudies-literature
UnknownCEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2.
Not available
S-EPMC11574021 | biostudies-literature
UnknownStructural basis for CEP192-mediated regulation of centrosomal AURKA.
Not available
S-EPMC10121170 | biostudies-literature
UnknownFBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
Not available
S-EPMC5836097 | biostudies-literature
UnknownCEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
Not available
S-EPMC9551108 | biostudies-literature
UnknownMosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
Not available
S-EPMC10716027 | biostudies-literature
UnknownCep192, a Novel Missing Link between the Centrosomal Core and Corona in Dictyostelium Amoebae.
Not available
S-EPMC8467581 | biostudies-literature
UnknownThe Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.
Not available
S-EPMC4245277 | biostudies-literature
UnknownPHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.
Not available
S-EPMC3757158 | biostudies-literature
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