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ProteomicsRBM39 organizes an m⁶A-dependent silencing complex to degrade Tat mRNA and maintain HIV-1 latency
To further elucidate the interaction between RBM39 and its partern proteins, Flag-tagged RBM39 were transfected into HEK293T cells. After transfection, RBM39 and RBM39-bound proteins were enriched using anti-Flag beads. Subsequently, the enriched proteins were separated by SDS-PAGE and analyzed by L...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD064858 | Pride
Lc/ms Hek293t Rbm39 Co-ip 
ProteomicsThe research of RBM39 in multiple myeloma
RBM39 is a RNA binding protein, we aim to investigate its role in multiple myeloma. We performed mass spectrometry of RBM39 interacted protein obtained by IP.
ORGANISM(S): Homo Sapiens 
2025-02-09 | PXD060610 |
ProteomicsStructural complementarity offsets low receptor affinity in E7820-mediated RBM39 degradation by CRL4DCAF15
The investigational drugs E7820, indisulam and tasisulam (aryl-sulfonamides) promote the degradation of the splicing factor RBM39 in a proteasome and CRL4DCAF15 ubiquitin ligase-dependent mechanism, however the molecular details of this activity remain elusive. Here we present the cryo-EM structure ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-10 | PXD014536 | Pride
Dcaf15 E7820 Crl4 Sulfonamide Ubiquitin Cullin Rbm39 
GenomicsMORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to promote EMT and metastasis in colon cancer [RBM39 RIP-seq]
MORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to promote EMT and metastasis in colon cancer [RBM39 RIP-seq]
PRJNA1034067 | ENA
GenomicsZCCHC10 promotes RBM39 degradation to suppress RBM39-mediated mis-splicing in acute myeloid leukemia
ZCCHC10 promotes RBM39 degradation to suppress RBM39-mediated mis-splicing in acute myeloid leukemia
PRJNA1181249 | ENA
GenomicsIdentification of RBM39-dependent alternative splicing events in HeLa cells
Identification of RBM39-dependent alternative splicing events in HeLa cells
PRJNA834774 | ENA
ProteomicsA Molecular Glue of RBM39 and DCAF15 Arrests Cell Cycle Progression by Downregulation of CEP192
RBM39 is a crucial component of the spliceosome that is critical for the integrity of mature mRNA, while depletion of RBM39 by Indisulam significantly increases RNA splicing defects. The antitumor activity of Indisulam is partially attributed to its inhibitory effects on cell cycle progression. To i...
ORGANISM(S): Homo sapiens (Human) 
2025-03-20 | PXD056341 | Pride
Rbm39 Cep192 Indisulam Proteomics analysis Cell cycle arrest 
GenomicsGenome-wide chromatin occupancy of RBM39 and MLL1 in T47D cells
Genome-wide chromatin occupancy of RBM39 and MLL1 in T47D cells
PRJNA603523 | ENA
GenomicsExceptional response of high-risk neuroblastoma to RBM39 degrader Indisulam (RNA-Seq)
Exceptional response of high-risk neuroblastoma to RBM39 degrader Indisulam (RNA-Seq)
PRJNA691032 | ENA
UnknownSystematic pan-cancer analysis identifies RBM39 as an immunological and prognostic biomarker.
Not available
S-EPMC9465192 | biostudies-literature
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