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MetabolomicsLong-term metabolic profiling in transient middle cerebral artery occlusion (tMCAO) mouse model
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ORGANISM(S): Mus musculus 
ST002042 | MetabolomicsWorkbench
MetabolomicsLC-MS-Based Serum Metabolomics Reveals Distinct Metabolic Signatures in Patients with Cerebral Infarction

This study applied serum metabolomics to compare patients with cerebral infarction (n=10) and controls (n=10). A total of 3,160 metabolites were identified, with distinct class distributions between groups. Cerebral infarction patients showed elevated benzene derivatives, organic acids, and bile ...

2025-09-24 | MTBLS13031 | MetaboLights
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old Htra1 KO and wild type mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-02 | PXD022298 | JPOST Repository
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old candesartan-treated and nontreated Htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. Htra1-KO m...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-16 | PXD023477 | JPOST Repository
MetabolomicsIntegrated Analysis of Gut Microbiota, Serum Metabolomics, and Proteomics Reveals Novel Associations With Clinical Symptoms in Patients With Cerebral Infarction
Cerebral infarction (CI) is a major cause of adult disability and mortality worldwide. Mounting evidence supports the critical role of the gut–brain axis in cerebrovascular disease progression. This study aimed to characterize the alterations in gut microbiota, serum metabolome, and serum proteome i...
2026-05-08 | MTBLS14356 | MetaboLights
MetabolomicsIntegrated multi-omics reveals gut microbiota–metabolic mechanisms underlying the neuroprotective effects of Xijiao Dihuang Decoction against cerebral ischemia–reperfusion injury
This study investigated the effects of Xijiao Dihuang Decoction (XDD) on cerebral ischemia–reperfusion injury using a middle cerebral artery occlusion/reperfusion rat model. Untargeted LC–MS metabolomics was performed on fecal samples to characterize metabolic alterations associated with MCAO/R and ...
2026-09-23 | MTBLS15783 | MetaboLights
TranscriptomicsTranscription profiling of mouse forebrain with induced middle cerebral artery occlusion (MCAO) to study permanent focal cerebral ischemia
profiling gene transcription in a mouse model of permanent focal cerebral ischemia that was induced by middle cerebral artery occlusion (MCAO)
ORGANISM(S): Mus musculus 
2009-03-07 | E-TABM-655 | biostudies-arrayexpress
MetabolomicsTherapeutic Effect of Buyang Huanwu Decoction on the Gut Microbiota and Hippocampal Metabolism in a Rat Model of Cerebral Ischemia

Buyang Huanwu decoction (BHD) is a well-known Chinese herbal prescription. It has been widely used in the clinical treatment of cerebral ischemia (CI) in China. However, the mechanism underlying the treatment of CI with BHD remains to be elucidated. In this study, we combined microbiomic and meta...

2022-06-02 | MTBLS4366 | MetaboLights
MetabolomicsMetabolome of 334 cerebral thrombi (in four batches) retrieved by mechanical thrombectomy after ischemic stroke due to large vessel occlusion (Retro-MATISSE study)

The Retro-MATISSE study (Molecular Analysis of Thrombus for Ischemic Stroke prognosiS and Etiology) aimed to characterize the metabolome of 334 thrombi <...

2026-04-25 | MTBLS14374 | MetaboLights
ProteomicsEffect of age on the vascular proteome in middle cerebral arteries and small mesenteric arteries in mice
Effect of age on the vascular proteome in middle cerebral arteries and small mesenteric arteries in mice
ORGANISM(S): Mus Musculus (mouse) 
2022-02-09 | PXD024070 | JPOST Repository
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