Cerebral organoids

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Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 138648 Singapore, Singapore. Department of Pharmacy, National University of Singapore, 117543, Singapore, Singapore. (1)
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Group for BIoanalysis, Korea Research Institute of Standards and Science (KRISS), Daejeon, Republic of Korea (1)
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Lab of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil. (1)
Lab of Neuroproteomics, Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil. (1)
Loschmidt Laboratories Department of Experimental Biology & RECETOX Faculty of Science, Masaryk University (1)
MRC Laboratory of Molecular Biology (1)

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EVOLUTION OF THE LIPIDOME UNCOVERS EARLY CHANGES IN ADRENOLEUKODYSTROPHY HUMAN CORTICAL AND SPINAL ORGANOIDS

Lipids are critical for the structure, signaling, and metabolism of the central nervous system (CNS), yet their roles during human brain development remain underexplored due to limited tissue availability. X-linked adrenoleukodystrophy (ALD), a peroxisomal disorder caused by ABCD1 mutat...

2025-11-17 | MTBLS12973 | MetaboLights

Mass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights

Lineage recording in human cerebral organoids (whole organoids)

Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectori...

ORGANISM(S): Homo sapiens

2021-11-03 | E-MTAB-10974 | biostudies-arrayexpress

Cerebral organoids proteomics - Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities

Pluripotent stem cells (PSC) can differentiate inot any cell type of an organism. Their remarkable capability of self-organization enables the formation of three-dimensional structures that resembles miniature organs, including cerebral organoids. These organoids can recreate early steps of the hum...

ORGANISM(S): Homo sapiens (Human)

2019-11-15 | PXD011605 | Pride

Proteome landscape of schizophrenia in patient-derived cerebral organoids

We utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. ...

ORGANISM(S): Homo sapiens (Human)

2021-11-17 | PXD027812 | Pride

Schizophrenia Ipsc Proteome Cerebral organoids Neuropathology

Lineage recording in human cerebral organoids (Visium)

ORGANISM(S): Homo sapiens

2021-11-03 | E-MTAB-10972 | biostudies-arrayexpress

Lineage recording in human cerebral organoids (iTracer-perturb)

ORGANISM(S): Homo sapiens

2021-11-03 | E-MTAB-10971 | biostudies-arrayexpress

Lineage recording in human cerebral organoids (microdissected)

ORGANISM(S): Homo sapiens

2021-11-03 | E-MTAB-10973 | biostudies-arrayexpress

Single cell RNA-seq of great ape cerebral organoids

The human brain has changed dramatically from other primate species, but the genetic and developmental mechanisms behind the differences remains unclear. Here we used single cell RNA sequencing based on 10X technology to explore temporal transcriptomic dynamics and cellular heterogeneity in cerebral...

ORGANISM(S): Pan troglodytes

2019-12-30 | E-MTAB-7552 | biostudies-arrayexpress

Proteomic analysis of Cerebral organoid-derived exsome

In this study, we provides a comprehensive analysis of proteomic changes in exosomes derived from cerebral organoids during neuronal differentiation.

ORGANISM(S): Homo sapiens (Human)

2026-04-27 | PXD063105 | Pride

Exosome Cerebral organoids Proteome

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