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MetabolomicsDistinct Cervical Microbiome and Metabolite Profiles Before and After Menopause: Implications for Cervical Cancer Progression

Introduction: Cervical cancer is the fourth most common malignancy in women and is primarily caused by persistent infection with high-risk human papillomavirus (HPV). In addition, host immune responses, genetic factors, and lifestyle habits also have etiological roles. The cervicovaginal microbio...

2025-07-07 | MTBLS12691 | MetaboLights
ProteomicsMucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human endo- and ecto-cervix chips
Modulation of mucus production by the human ecto- and endo-cervical epithelium by steroid hormones and associated interactions with commensal microbiome play a central role in the physiology and pathophysiology of the female reproductive tract. However, most of our knowledge about these interactions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-26 | MSV000091806 | MassIVE
ProteomicsProteomics of cervical mucus in natural and stimulated cycle
Cervical mucus is a viscous fluid functioning as a uterine cervix plug. It is formed and produced by cervical glands located in the cervix. During ovulation, cervical mucus starts to become less viscous, which is a good window for non-invasive sampling. Our study focuses on the proteomic characteriz...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD037654 | Pride
Cervix Fluid Cancer Endometrioisis Proteomics Endometrium Receptivity Mucus Biomarker 
ProteomicsProteomics of Human Cervical Mucus Plugs
Preterm birth is a leading cause of neonatal mortality and lacks an effective therapy. Ascending microbial infections from the lower genital tract lead to infection of the placenta, amniotic fluid and fetus causing preterm birth or stillbirth. Directly in the path of an ascending infection is the ce...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD008600 | Pride
Mass spectrometry Proteomics Proteins Human Antimicrobial Peptides Cervical mucus plugs 
GenomicsmicroRNA profile in the cervical mucus of the cervical neoplasia
microRNA profile in the cervical mucus of the cervical neoplasia
PRJNA415128 | ENA
TranscriptomicsRNA-seq profiling of the bovine cervix at 6 timepoints during the peri-oestrus period.
The estrous cycles of Limousin heifers (n = 30) were synchronized by insertion of a controlled internal drug release (CIDR) device (1.94 g progesterone; Pfizer Animal Health) placed into the vagina for 8 days. A 0.5 mg intramuscular injection of a prostaglandin F2α (PG) analogue (PG, Estrumate, Sher...
ORGANISM(S): Bos taurus 
2013-01-04 | E-GEOD-38225 | biostudies-arrayexpress
ProteomicsMmulatta - Cervical mucus, iBAQ (Hanetal,proteomicsclinappl2021)
abundance based on iBAQ, Interaction consistency score: 11.2, Coverage: 12
ORGANISM(S): 9544 
2021-00-00 | 3696013597 | PAXDB
ProteomicsH.sapiens - Cervical mucus, iBAQ (Hanetal,proteomicsclinappl2021)
abundance based on iBAQ, Interaction consistency score: 9.4, Coverage: 15
ORGANISM(S): 9606 
2021-00-00 | 3775906933 | PAXDB
ProteomicsComparing Endocervical Mucus Proteome of Humans and Rhesus Macaques
Endocervical mucus changes play a key role in regulating fertility throughout the menstrual cycle and in response to hormonal contraceptives. Non-human primates (NHP) provide the most translational animal model for reproductive tract studies, as they have hormonally-regulated menstrual cycles and mu...
ORGANISM(S): Homo sapiens (Human) Macaca mulatta (Rhesus macaque) 
2021-05-21 | PXD021710 | Pride
Human Tmt labeling Endocervical mucus Quantitative proteomics Primate 
GenomicsmicroRNA profile in the cervical mucus of the cervical neoplasia
Cervical mucus was collected from 86 patients with a normal cervix, cervical intraepithelial neoplasia (CIN), squamous cell carcinoma (SCC), or adenocarcinoma (AD). 76 candidates of miRNAs were selected according to criteria such as absolute value of the signal intensity included more than 20 and th...
ORGANISM(S): Homo sapiens 
2018-05-09 | GSE105409 | GEO
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