Sort   by:  
 Page size 
GenomicsCFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis
PRJNA744418 | ENA
ProteomicsSRSF7 and SRSF3 affectSRSF7 and SRSF3 affect 3’UTR length in opposite directions by controlling proximal poly(A)-site usage and CFIm levels 3’UTR length in opposite directions by controlling proximal poly(A)-site usage and CFIm levels
Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which affects the length of their 3’ untranslated regions (3’UTRs). APA regulates stage- and tissue-specific gene expression by affecting the stability, subcellular localization or tra...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018090 | Pride
Mace Dapars Cfim Cpsf5 Srsf7 Cpsf6 Fip1 Srsf3 Poly(a) site Iclip Alternative polyadenylation 
TranscriptomicsCFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis
The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation (APA) in a broad range of contexts, from cancers to learning deficits and parasite infections. To determine how the CFIm expression levels are translated into these diverse phenotypes, we carried out a multi-om...
ORGANISM(S): Homo sapiens 
2022-02-16 | GSE179630 | GEO
UnknownCFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis.
Not available
S-EPMC8989530 | biostudies-literature
UnknownMolecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation.
Not available
S-EPMC5756121 | biostudies-literature
UnknownLoss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAness.
Not available
S-EPMC12633455 | biostudies-literature
UnknownA stress-dependent postembryonic role for the core CPA factor CFIM-1 in germline integrity.
Not available
S-EPMC12236649 | biostudies-literature
ProteomicsA jack of all trades and a master of some: remodeling of signaling pathways downstream of CFIm 3’ end processing factor
The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation (APA) in a broad range of contexts, from cancers to learning deficits and parasite infections. To uncover the molecular pathways that translate CFIm expression levels into these observed phenotypes, we carried ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD027034 | Pride
Tmt Phosphorylation Cfim3 
UnknownSRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.
Not available
S-EPMC7948361 | biostudies-literature
ProteomicsInteracting proteins of NUDT21 identified by IP-MS
Alternative polyadenylation modulates gene expresion via changing the length of 3'UTR. Among the complexes involving in APA, CFIm complex plays a central role in determining the usage of proximal PAS versus distal one. NUDT21, also named as CFIm25 and CPSF5, is the core component of CFIm complex. To...
ORGANISM(S): Homo Sapiens 
2022-01-21 | PXD031134 |
Sort   by:  
 Page size