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FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts wit...

2024-03-24 | MTBLS206 | MetaboLights

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
In this work, we developed a suite of linked-domain UBE2D inhibitors. We transfected these constructs into HeLa cells and used shotgun proteomics with label-free quantification to measure which protein's abundances are affected by UBE2D inhibition.
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD040264 | Pride
Here we used a his-tagged version of the UD1long UBE2D inhibitor to pulldown protein from HeLa cell extract
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD065412 | Pride
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