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UnknownStructures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope
Not available
S-SCDT-10_1038-S44319-026-00716-5 | biostudies-other
TranscriptomicsMast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
We found that AhR, a unique chemical sensor, is critical in controlling mast cell differentiation, growth and function in vitro and in vivo. This study seeks to further the understanding of the mechanisms of how AhR control mast cell homeostasis. Three different batches of bone marrow derived mast c...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44715 | biostudies-arrayexpress
TranscriptomicsExpression data of sorted GFP+ and tdTomato+ prostate tumor cells from Pten/Smad4/mTmG mice
Single cells from Ptenpc-/-Smad4pc-/-mTmG+ prostate tumors were isolated into single cells which were FACS-sorted for GFP+ and Tomato+ cells and RNA was purified with TRIzol (Life Technologies). RNA expression profiling was performed using the Mouse Genome 430 2.0 Array (Affymetrix) to generate a P...
ORGANISM(S): Mus musculus 
2016-02-03 | E-GEOD-71319 | biostudies-arrayexpress
UnknownInfluenza-Host Interplay and Strategies for Universal Vaccine Development.
Not available
S-EPMC7564814 | biostudies-literature
TranscriptomicsA subcutaneous adipose tissue-liver axis in the control of hepatic gluconeogenesis
We performed RNA sequencing analysis of hepatic gene expression a few hours after amlexanox treatment, and identified over 1700 differentially expressed genes. Pathway analysis of these differentially regulated genes revealed that the top two most enriched pathways were the adipocytokine signaling p...
ORGANISM(S): Mus musculus 
2015-04-17 | E-GEOD-57054 | biostudies-arrayexpress
ProteomicsRegulation of the ER stress response by a mitochondrial microprotein
Cellular homeostasis relies on having dedicated and coordinated responses to a variety of stresses. The accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a common stress that triggers a conserved pathway called the unfolded protein response (UPR) that mitigates damage, and dysre...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014890 | Pride
Mitochondrial Smorfs Microprotein Er stress response 
UnknownEnhanced Nitric Oxide Sensing Performance of Conjugated Polymer Films through Incorporation of Graphitic Carbon Nitride.
Not available
S-EPMC9864893 | biostudies-literature
TranscriptomicsAtSeedlingRootMunitionResponses
Roots transcriptome responses 14-day old Arabidopsis seedlings grown submerged in MS medium and exposed to TNT or RDX. Keywords = phytoremediation Keywords = explosives Keywords = TNT Keywords = RDX Keywords: parallel sample Complete experiment contains only three samples, including the control.
ORGANISM(S): Arabidopsis thaliana 
2003-07-30 | E-GEOD-560 | biostudies-arrayexpress
TranscriptomicsThe glycogen scaffolding protein PTG coordinately regulates glycogen and lipid storage
Glycogen and lipid are major storage forms of energy that are tightly regulated by hormones and metabolic signals. Here, we evaluate the role of the glycogenic scaffolding protein PTG/R5 in energy homeostasis. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen, corresp...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-45319 | biostudies-arrayexpress
TranscriptomicsSystems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis
Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. We defined the global early immune response to MRKAd5/HIV by profiling the PBMC transcriptomes from seven Ad5Neg individuals pre- and...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22768 | biostudies-arrayexpress
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