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Steady-state gene expression is a coordination of synthesis and decay of RNA through epigenetic regulation, transcription factors, miRNAs, and RNA-binding proteins. Here, we present Bru-Seq and BruChase-Seq to assess genome-wide changes to RNA synthesis and stability in human fibroblasts at homeosta...
ORGANISM(S): Homo sapiens 
Lee SY, Chea JS, Zhao BX, Xu C, Udeshi ND, Roh H, Kim C, Cho K, Carr SA, Ting A. 2022 The incorporation of light-responsive domains into engineered proteins has produced optogenetic tools with the ability to regulate protein localization, interactions, and function with light. We introduced this mod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-09 | MSV000090683 | MassIVE
PROTACs (Proteolysis-Targeting Chimeras) represent a revolutionary new class of drugs that selectively degrade proteins of interest from cells. PROTACs targeting oncogenes are avidly being explored for cancer therapies, with several currently in clinical trials. Drug resistance represents a signif...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD029233 | Pride
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