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UnknownCENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.
Not available
S-EPMC3277711 | biostudies-literature
Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054179 | Pride
Translation Ribosomes Mitosis Cell cycle 
ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-07 | PXD054183 | Pride
Translation Ribosomes Mitosis Cell cycle 
TranscriptomicsPopulation structure shapes copy number variation in malaria parasites
If copy number variants (CNVs) are predominantly deleterious, we would expect them to be more efficiently purged from populations with a large effective population size (Ne) than from populations with a small Ne. Malaria parasites (Plasmodium falciparum) provide an excellent organism to examine this...
ORGANISM(S): Plasmodium falciparum 
2015-11-19 | E-GEOD-75137 | biostudies-arrayexpress
ProteomicsSRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program
Alternative splicing expands proteomic diversity and is tightly regulated by splicing factors, including the serine/arginine-rich (SR) protein family. Here, we analyze the poorly characterized protein SRSF12. Although SRSF12 is conserved across vertebrates, it is poorly expressed in most mammals, an...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD066334 | Pride
Splicing Ip-ms Srsf 
UnknownMigratory destinations and spatial structuring of humpback whales (Megaptera novaeangliae) wintering off Nicaragua.
Not available
S-EPMC10500005 | biostudies-literature
UnknownDynamic cell cycle-dependent phosphorylation modulates CENP-L-CENP-N centromere recruitment.
Not available
S-EPMC9582625 | biostudies-literature
UnknownA mouse model for osseous heteroplasia.
Not available
S-EPMC3526487 | biostudies-literature
ProteomicsAlternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease
Mitochondrial acquisition was a pivotal event in eukaryotic evolution, requiring core proteins adapt to function both within the mitochondria and in the host cell. Here, we systematically profile the localization of protein isoforms generated by alternative start codon selection. We identify hundred...
ORGANISM(S): Homo sapiens (Human) 
2025-10-28 | PXD062112 | Pride
Mrps38 Ribosomes Mitochondria Aurkaip1 
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