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MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
MetabolomicsAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation

Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical m...

2026-05-07 | MTBLS14445 | MetaboLights
ProteomicsCombined Metabolic and Chemical (CoMetChem) labeling using stable isotopes
Histone acetylation is an important, reversible posttranslational protein modification and hallmark of epigenetic regulation. However, little is known about the dynamics of reversible hisotne acetylation, due to the lack of analytical methods that can capture site-specific acetylation and deacetylat...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD027338 | Pride
Lc-msms Stable isotopes Acetylation Histones 
GenomicsChIP-seq analysis of H3K9 acetylation enrichment in hESCs and day 8 neural progenitor cells
H3K9 acetylation was enriched in pluripotency genes in hESCs and in neural genes in neural progenitor cells Examination of H3K9 acetylation distributions in hESCs and neural progenitor cells
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-66778 | biostudies-arrayexpress
ProteomicsA Chemical Acetylation based Mass Spectrometry Platform for Histone Profiling
Here we present a strategy for the identification and quantitation of histone methylation that utilizes nondeuterated acetic anhydride to fully acetylate all free lysine residues prior to digestion with trypsin and analysis by LC-MS/MS.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086146 | MassIVE
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081704 | MassIVE
ProteomicsIn-vitro acetylation assay of TULP3
Fig. S1D: An in-vitro assay that identified the acetylation sites on recombinant TULP3 with the addition of recombinant human p300.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-20 | MSV000086340 | MassIVE
GenomicsHistone acetylation regulates intracellular pH
Differences in global levels of histone acetylation occur in normal and cancer cells, although the reason cells regulate these levels has remained unclear. Here we demonstrate a role for histone acetylation in regulating intracellular pH (pHi). As pHi decreases, histones are globally deacetylated by...
ORGANISM(S): Homo sapiens 
2012-11-04 | E-GEOD-40114 | biostudies-arrayexpress
GenomicsAF9 Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
The recognition of modified histones by “reader” proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the great variety of readers for histone methylation, few protein modules that recognize histone acetylation are known. Here we show that the evolu...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-60366 | biostudies-arrayexpress
ProteomicsAnalysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions
Acetylation is frequently detected on mitochondrial enzymes and the sirtuin deacetylase SIRT3 is thought to regulate metabolism by deacetylating mitochondrial proteins. However, the stoichiometry of acetylation has not been studied and is important for understanding whether SIRT3 regulates or suppre...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-15 | PXD000885 | Pride
Sirt3 Stoichiometry Acetylation Liver 
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