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ProteomicsA Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation
L-Lactylation is a recently discovered post-translational modification occurring on histone lysine residues to regulate gene expression. However, the substrate scope of lactylation, especially that in non-histone proteins, remains unknown, largely due to the limitations of current methods for analyz...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033454 | Pride
Chemical reporter Chemical proteomics Lactylation 
UnknownA chemical reporter for protein AMPylation.
Not available
S-EPMC3246509 | biostudies-literature
ProteomicsNuclear receptor chemical reporter enables domain-specific analysis of ligands in mammalian cells
The characterization of specific metabolite–protein interactions is important in chemical biology and drug discovery. For example, nuclear receptors (NRs) are a family of ligand-activated transcription factors that regulate diverse physiological processes in animals and are key targets for therapeut...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020969 | Pride
Lc-msms 
UnknownA bioorthogonal chemical reporter for the detection and identification of protein lactylation.
Not available
S-EPMC9132054 | biostudies-literature
TranscriptomicsSequential stage specific reporter line analysis (SSRLA) of 3 BAC transgenic mESC lines
FACS purified cells from differentiation day 14-15 cells from 3 BAC transgenic mESC lines: Hes::GFP (early), Nurr1::GFP (mid), and Pitx3::YFP (late) DA neuron development reporter lines All three lines were differentiated towards the midbrain dopamine phenotype, and FACS purification was performed ...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37446 | biostudies-arrayexpress
UnknownA light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules.
Not available
S-EPMC9092362 | biostudies-literature
UnknownNuclear Receptor Chemical Reporter Enables Domain-Specific Analysis of Ligands in Mammalian Cells.
Not available
S-EPMC8147873 | biostudies-literature
TranscriptomicsA Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients' Plasma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-49758 | biostudies-arrayexpress
ProteomicsA bioorthogonal chemical reporter for fatty acid synthase-dependent protein acylation
Mammalian fatty acid synthase (FASN) is a lipogenic enzyme that catalyzes the formation of the long chain saturated fatty acid palmitate from acetyl and malonyl CoA in the presence of NADPH. Mammalian cells acquire fatty acids through dietary sources or through FASN. Although most mammalian cells ex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028244 | Pride
Fatty acid synthase N-myristoylation Protein acylation Click chemistry S-palmitoylation 
ProteomicsS-acylated and S-palmitoylated proteins in HeLa
S-fatty-acylation is the covalent attachment of long chain fatty acids, predominately palmitate (C16:0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on proteins. This post-translational and reversible lipid modification regulates protein function and localization in eukaryot...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD008398 | Pride
Hela Label free quatification S-acylation Acyl-rac S-palmitoylation Alk-16 chemical reporter Fatty acylation Lc-ms/ms 
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