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UnknownOptimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.
Not available
S-EPMC9245059 | biostudies-literature
ProteomicsProteome of the polar filament and polar tube of Nosema bombycis
The polar filaments and polar tubes of Nosema bombycis were successfully purified by differential centrifugation, and the protein components were identified by proteomic methods, and the functions of these proteins were commented. These results will provide some reference value and significance for ...
ORGANISM(S): Nosema Bombycis Cq1 
2022-04-06 | PXD033032 |
ProteomicsDifferential Proteomic Analysis of Fetal and Geriatric Lumbar Nucleus Pulposus
Intervertebral disc degeneration (IVDD) is a main cause of degenerative disc disease, which results in substantial pain among patients. However, the mechanism of degeneration remains unclear. Thus far, basic research on human IVDD has focused on only a limited number of proteins and has not been con...
ORGANISM(S): Homo Sapiens 
2020-05-02 | PXD015000 |
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
ProteomicsIdentification of Silkworm Organelle Proteome
Isolate silkworm proteins in organelles of nucleus, cytosol, mitochondria and endoplasmic reticulum , and determine the proteins using mass spectrum
ORGANISM(S): Bombyx Mori 
2021-05-06 | PXD025816 |
TranscriptomicsMapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population [SNP analysis]
Elucidating the genetic basis underlying the variation in hepatic gene expression is of importance to understand disease etiology and drug metabolism variances. To date, no genome-wide eQTL analysis has been conducted in the Han Chinese, the largest ethnic group in the world. We performed a genome-w...
ORGANISM(S): Homo sapiens 
2015-01-02 | E-GEOD-53790 | biostudies-arrayexpress
TranscriptomicsMapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population [Expression analysis]
Elucidating the genetic basis underlying the variation in hepatic gene expression is of importance to understand disease etiology and drug metabolism variances. To date, no genome-wide eQTL analysis has been conducted in the Han Chinese, the largest ethnic group in the world. We performed a genome-w...
ORGANISM(S): Homo sapiens 
2015-01-02 | E-GEOD-53791 | biostudies-arrayexpress
ProteomicsProteomic analysis of PDCoV-infected HIEC-6 cells
Data-independent acquisition (DIA) is a new type of mass spectrometry data acquisition developed in recent years. The entire scanning range of mass spectrometry can be divided into several windows based on the mass-to-charge ratio (m/z), and then all the parent ions in each window are fragmented and...
ORGANISM(S): Homo Sapiens 
2024-02-20 | PXD049713 |
ProteomicsThe global succinylation of SARS-CoV-2-infect host cells reveals potential drug targets
Here we show a quantitative mass spectrometry-based succinylproteomics analysis of SARS-CoV-2 infection in Caco-2 cells, revealing dramatic reshape of succinylation on host and viral proteins.
ORGANISM(S): Homo Sapiens 
2021-12-06 | PXD030197 |
ProteomicsSS18 regulates pluripotent-somatic transition through phase separation
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
2021-05-23 | PXD026208 |
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