Sort   by:  
 Page size 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
TranscriptomicsEffect of T350 phosphorylation on gene repression activity of EZH2 in BJ cells
The Polycomb group (PcG) protein enhancer of zeste homolog 2 (EZH2) plays an essential role in histone methylation-mediated epigenetic gene silencing. We demonstrate that under physiological conditions, cyclin-dependent kinase 1 (CDK1) and 2 (CDK2) bind to and phosphorylate EZH2 at threonine 350 (T3...
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-22427 | biostudies-arrayexpress
TranscriptomicsEffects of T350 phospho- on gene repression activity of EZH2
The Polycomb group (PcG) protein enhancer of zeste homolog 2 (EZH2) plays an essential role in histone methylation-mediated epigenetic gene silencing. We demonstrate that under physiological conditions, cyclin-dependent kinase 1 (CDK1) and 2 (CDK2) bind to and phosphorylate EZH2 at threonine 350 (T3...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-20433 | biostudies-arrayexpress
ProteomicsA rapid and convenient sample treatment method based on the dissolvable polyacrylamide gel for S-acylation proteomics
S-acylation, dissolvable gel, sample treatment, proteomics
ORGANISM(S): Mus Musculus 
2024-06-04 | PXD052808 |
UnknownThree dimensional collagen scaffolds promote iPSC induction with higher pluripotency.
Not available
S-EPMC5084158 | biostudies-literature
ProteomicsA lncRNA from the FTO locus acts as an inhibitor of the m6A writer complex and p53 tumor suppression signaling
control RNA and FTO-IT1 RNA and their interacting proteins were pulled down by biotin-streptavidin beads to see the interacting protein of FTO-IT1 RNA.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD041053 | Pride
Fto-it1 Prostate cancer 
ProteomicsN-glycopeptide Signatures in AFP-negative HCC
Serum N-linked intact glycopeptides was investigated in AFP-negative HCC and cirrhosis (LC) patients by using label-free quantification methodology.
ORGANISM(S): Homo Sapiens 
2021-01-11 | PXD023500 |
ProteomicsHigh-Throughput Intact Glycopeptide Quantification Strategy with Targeted-MS (HTiGQs-Target) Reveals Site-Specific IgG N-Glycopeptides as Biomarkers for Hepatic Disorder Diagnosis and Staging
We developed a high-throughput targeted quantification strategy for intact glycopeptides (HTiGQs-Target) to diagnose and differentiate the malignancy of liver diseases. The method involves two-step labeling. This step derivatization makes the same parent ions in different samples produce sufficient ...
ORGANISM(S): Homo Sapiens 
2023-05-30 | PXD042528 |
ProteomicsComprehensive N-Glycomics Profiling of Urinary Extracellular Vesicles Identifies a Novel Biomarker Panel for Diagnosis of Bladder Cancer
Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges.Urinary extracellular vesicles (EVs) is a particularly promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. We investigate bioma...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057882 |
Sort   by:  
 Page size