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Data from ProteomeXchange, PXD ID: PXD001078. File: folder summary. Published as part of J Proteome Res. 2015 Feb 6;14(2):1250-62 . From the Abstract: {{i}} ... Treatment of triple-negative breast cancer (TNBC) is complex and challenging, especially when metastasis has developed. In this study, we ...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
Here, we decipher the molecular mechanisms bridging B cell activation and apoptosis mediated by post-translational modification(PTM). We found that O-GlcNAcase inhibition enhances B cell activation and apoptosisinduced by B cell receptor (BCR)cross-linking. This proteome-scale analysis of the functi...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-26 | PXD003788 | Pride
we applied label-free quantitative phosphoproteomic analysis to delineate the dynamics of galectin-1-induced signaling in comparison with the first systematic phosphorylation-mediated signaling network in B cell activation by anti-IgM treatment.
ORGANISM(S): Mus musculus (Mouse) 
2016-03-15 | PXD000762 | Pride
Ovarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Although O-mannosyltransferase TMTC1 is highly expressed by ovarian cancer, its pathophysiologic role in ovarian cancer remains unclear. Here, immunohistochemistry showed that TMTC1...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037907 | Pride
Immunotherapy has revolutionized cancer treatment, however, a reliable biomarker is missing. MGAT5-mediated PD-L1 glycosylation is critical for its interaction with PD-1. MGAT5 expression is a functional biomarker that predicts immunotherapy responses.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045506 | Pride
In this study, a novel IR-binding protein (IRBP) from Momordica charantia, named as mcIRBP, was identified by analyzing the physical and functional interactions between mcIRBP and IR. The hypoglycemic effect and mechanism of mcIRBP were further evaluated in normal and streptozotocin-induced diabetic...
ORGANISM(S): Mus musculus 
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